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Pharmacological Interaction of Botulinum Neurotoxins with Excitatory and Inhibitory Neurotransmitter Systems Involved in the Modulation of Inflammatory Pain [PDF]
ToxinsBotulinum neurotoxins (BoNTs) are known to inhibit synaptic transmission by targeting SNARE proteins, but their selectivity toward central excitatory and inhibitory pathways is not yet fully understood. In this study, the interaction of serotypes A (BoNT/
Sara Marinelli +2 more
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Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model [PDF]
Frontiers in Pain ResearchIntroductionThis study explores the analgesic potential of the novel conotoxin O1_cal6.4b, derived from Californiconus californicus, as a candidate for pain management in a model of inflammatory pain.MethodsO1_cal6.4b was systemically administered to ...
Joaquín López-Carrillo +11 more
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Frontiers in Bioscience-Landmark, 2021 Tetrahydropalmatine (dl-THP) demonstrates an analgesic effect in animal models of neuropathic and inflammatory pain, however, the underlying mechanisms of its pharmacological action within the spinal cord remains unclear. Both P2X3 receptor and TRPV1 are
Yan Wang +8 more
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Non-inflammatory pain in inflammatory arthritis
Rheumatology, 2022 Abstract ‘Non-inflammatory’ pain, pain that is not associated with measures of inflammation, is common in patients with inflammatory arthritis including RA. One important cause of non-inflammatory pain is concomitant fibromyalgia. Systematic review has shown that fibromyalgia is common in inflammatory arthritis including RA affecting 1 ...
Dhivya Das, Ernest Choy
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Molecules, 2021 Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic ...
Natalia A. Shnayder +12 more
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Rheumatic Disease Clinics of North America, 2012 Inflammatory back pain (IBP) is a concept, which elements characterize the spinal involvement of patients with ankylosing spondylitis (AS) and axial spondyloarthritis (axSpA). The identification of patients with IBP depends on the clinical setting and the diagnostic value of several IBP criteria.
Rubén, Burgos-Vargas, Jürgen, Braun
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Role of Resolvins in Inflammatory and Neuropathic Pain
Pharmaceuticals, 2023 Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain.
Jaeik Park +5 more
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Interleukin-17 as a potential therapeutic target for chronic pain
Frontiers in Immunology, 2022 Chronic pain remains to be a clinical challenge and is recognized as a major health problem with varying impacts on quality of life. Currently, the first-line therapy for chronic pain is opioids, which are often accompanied by unwanted psychoactive side ...
Xiaojuan Jiang +11 more
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Effect of palmitoylethanolamide on inflammatory and neuropathic pain in rats [PDF]
Korean Journal of Anesthesiology, 2017 BackgroundA growing body of evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of mast cells and glial cells, and production of inflammatory mediators in the peripheral and central nervous systems,
Tai-Kyung Seol +6 more
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Dimethyl Itaconate Attenuates CFA-Induced Inflammatory Pain via the NLRP3/ IL-1β Signaling Pathway
Frontiers in Pharmacology, 2022 Itaconate plays a prominent role in anti-inflammatory effects and has gradually been ushered as a promising drug candidate for treating inflammatory diseases. However, its significance and underlying mechanism for inflammatory pain remain unexplored.
Jiaqi Lin +8 more
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