Results 151 to 160 of about 92,043 (285)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Biosimilars in Adult and Pediatric Noninfectious Uveitis. [PDF]

Clin Ophthalmol
Ploeger CG, Carvalho Soares Valentim C, Guner ME, Kabaalioglu Guner M.   +3 more
europepmc   +1 more source

Economic burden of hidradenitis suppurativa based on healthcare resource utilization: German claims data analysis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease affecting approximately 0.1% of the German population. Patients with HS require substantial healthcare resource utilization. This study aimed to assess the economic burden associated with HS in Germany.
Falk G. Bechara, Tanja Tran, Sandeep Kiri, Romy Bley, Kathrin Schlüter, Claudia Grellmann, Sima Melnik, Sylke Schneider‐Burrus   +7 more
wiley   +1 more source

Pharmacovigilance analysis of infliximab in inflammatory bowel disease: novel safety signals and sex-specific adverse event profiles from the FAERS database (2004-2024). [PDF]

Front Immunol
Liu W, Wang S, Wang G, Qiao Z, Rao L, Cheng L, Shen G.   +6 more
europepmc   +1 more source

Organizing pneumonia potentially caused by infliximab in a pediatric patient with ulcerative colitis. [PDF]

Allergy Asthma Clin Immunol
Lee B, Martin I, Bax K, Jeimy S.
europepmc   +1 more source

Efficacy and Safety of Second-Line Advanced Therapy After Vedolizumab in Ulcerative Colitis: A Multicenter Cohort Study From the GETAID. [PDF]

United European Gastroenterol J
Calméjane L, Reenaers C, Gay C, Amiot A, Nuzzo A, Vuitton L, Atanasiu C, Stefanescu C, Altwegg R, Guillo L, Serrero M, Bouguen G, Nachury M, Cosquer GL, Roblin X, Abitbol V, Hammoudi N, Simon M, Fumery M, Savoye G, Benezech A, Cavicchi M, Charkaoui M, Buisson A, Caron B, Coffin B, Geyl S, Goutorbe F, Hupé M, Vidon M, Laharie D, Kirchgesner J, Uzzan M, GETAID‐AFTER‐VEDO Study Group.   +33 more
europepmc   +1 more source

Alteration in oral and non‐oral tissues in ligature‐induced periodontitis mice with the Alzheimer's disease risk factor APOE4

European Journal of Oral Sciences, EarlyView.
Abstract The APOE4 gene, particularly the ε4 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)‐α regulation on the combined effects remain unclear.
Ae Ri Kim, Yun‐Jung Yoo, Eun‐Jung Bak   +2 more
wiley   +1 more source

Infliximab-Induced Pneumonitis in a Patient With Sarcoidosis: A Case Report. [PDF]

Open Respir Arch
Jiménez Romero AA, Guillamón Sánchez M, Velasco Alcazar MDC, Serrano Cortés C.   +3 more
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Persistence of advanced therapies in patients with ulcerative colitis: real-world data from the nationwide CREdIT registry. [PDF]

Ther Adv Gastroenterol
Hradsky O, Duricova D, Lukas M, Nedbalová L, Pipek B, Drastich P, Falt P, Vanasek T, Svikova J, Siroky M, Bouchner L, Svoboda P, Bronsky J, Bortlik M.   +13 more
europepmc   +1 more source