Results 41 to 50 of about 570,997 (263)
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Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
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Markov Influence Diagrams. [PDF]
Markov influence diagrams (MIDs) are a new type of probabilistic graphical model that extends influence diagrams in the same way that Markov decision trees extend decision trees. They have been designed to build state-transition models, mainly in medicine, and perform cost-effectiveness analyses.
Díez, F.J. +6 more
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The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
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Analysis of Gear Dynamic Characteristic of Oil Churning Resistance under Stochastic Disturbance
Oil churning lubrication is an important lubrication method of gear system. Considering the viscoelasticity of the lubricant oil will result in additional resistance upon gears immersed in the oil while running at high-speed,and the gear system can get ...
Wenyu Liu +4 more
doaj
Cost-effectiveness Analysis with Influence Diagrams [PDF]
SummaryBackground: Cost-effectiveness analysis (CEA) is used increasingly in medicine to determine whether the health benefit of an intervention is worth the economic cost. Decision trees, the standard decision modeling technique for non-temporal domains, can only perform CEA for very small problems.Objective: To develop a method for CEA in problems ...
M, Arias, F J, Díez
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Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
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Magnetic phase diagram of YbRh_{2}Si_{2}: The influence of hyperfine interactions
We report the determination of the magnetic phase diagram of the heavy fermion metal YbRh_{2}Si_{2} in magnetic fields up to 70 mT applied perpendicular to the crystallographic c axis.
J. Knapp +8 more
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Nonlinear Model and Dynamic Behavior of Photovoltaic Grid-Connected Inverter
A photovoltaic grid-connected inverter is a strongly nonlinear system. A model predictive control method can improve control accuracy and dynamic performance.
Zhi-Xian Liao +7 more
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Evaluating interval-valued influence diagrams
Este trabajo extiende el formalismo clásico de los Diagramas de Influencia para incluir parámetros cuantificados mediante intervalos, lo que permite un modelado más realista al considerar incertidumbre en los valores exactos. Se generalizan los algoritmos de Eliminación de Variables y Reversión de Arcos para manejar estos modelos, manteniendo la misma ...
Rafael Cabañas +3 more
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