Results 61 to 70 of about 593,613 (276)

Evaluating interval-valued influence diagrams

International Journal of Approximate Reasoning, 2017
Este trabajo extiende el formalismo clásico de los Diagramas de Influencia para incluir parámetros cuantificados mediante intervalos, lo que permite un modelado más realista al considerar incertidumbre en los valores exactos. Se generalizan los algoritmos de Eliminación de Variables y Reversión de Arcos para manejar estos modelos, manteniendo la misma ...
Rafael Cabañas, Alessandro Antonucci, Andrés Cano, Manuel Gómez-Olmedo   +3 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Bifurcation of Contact Between Rotor and Stator

MATEC Web of Conferences, 2012
The paper discusses Bifurcation Diagrams of rotor stator contact problems and the transition from synchronous whirl towards different asynchronous movement patterns.
Markert Richard, Alber Oliver
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Mechanics equilibrium in Tai-chi diagram

AIP Advances
Tai chi culture has a widespread influence on the world. Tai-chi diagrams, as the symbol of Tai chi culture, express the balance between Yin and Yang through the centrosymmetric pattern, but the balance connotation of Tai-chi diagrams needs a ...
Fei Dang, Qingquan Xiao, Pengfei Yang
doaj   +1 more source

Interval Influence Diagrams [PDF]

, 1990
We describe a mechanism for performing probabilistic reasoning in influence diagrams using interval rather than point valued probabilities. We derive the procedures for node removal (corresponding to conditional expectation) and arc reversal (corresponding to Bayesian conditioning) in influence diagrams where lower bounds on probabilities are stored at
openaire   +1 more source

Unconstrained Influence Diagrams

, 2012
Appears in Proceedings of the Eighteenth Conference on Uncertainty in Artificial Intelligence (UAI2002)
Jensen, Finn Verner, Vomlelova, Marta
openaire   +2 more sources