Results 121 to 130 of about 145,258 (308)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Nexus of Influencers and Purchase Intention: Does Consumer Brand Co-Creation Behavior Matter?

Journal of Theoretical and Applied Electronic Commerce Research
The advancement of social media has led to the rise of influencers who are powerful in shaping consumer purchasing behavior. While influencer attributes play a role in shaping consumer behavior, little attention has been paid to the interplay of the ...
Jerum William Kilumile, Li Zuo
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The influence of consumer ethnocentrism, influencers, personal innovativeness, and cultural intelligence on the choice of foreign tourist destinations

BizInfo
The process of globalization has implied greater interdependence of national cultures and economies, and the development of information technologies and transport services has made it easy to organize business and tourist trips to countries around the ...
Ivan Trifunović, Žaklina Spalević, Stefan Zdravković   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Influencers pediátricos en Instagram: divulgación sanitaria y promoción de la salud infantil

Vivat Academia
Introducción: La divulgación científica ha encontrado en las redes sociales una herramienta efectiva para adaptarse a los nuevos usos de interacción de audiencias jóvenes.
Maitane Palacios López, Paula Blanco González, Fernando Bonete Vizcaíno   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Impacto del uso de redes sociales e influencers sobre el conocimiento de marca y las ventas de automóviles de marcas emergentes en nuevos mercados

AD Research
Objetivo: entender el efecto que causan el uso de redes sociales y el apoyo de influencers sobre el conocimiento de marca y las ventas en los concesionarios automotrices de marcas emergentes en nuevos mercados.
Carlos Antonio Cuervo Sánchez
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Factors influencing brands’ reputation on social media

Management şi Marketing
Social networks considerably impact brand reputation, influencing consumer behaviour, perceptions, and purchase intentions. The content of brands on social media is central to consumer attitudes and behaviour and the formulation of opinions about the ...
Alves Joana, Teixeira Sara, Oliveira Zaila, Teixeira Sandrina   +3 more
doaj   +1 more source