Results 51 to 60 of about 919,130 (221)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Characterisation of antigen-presenting cells in the murine female reproductive tract and its draining lymph nodes [PDF]
, 2011 Despite the global burden of sexually transmitted diseases, the immunology of the female reproductive tract is poorly understood. An understanding of how the distribution of antigen presenting cells in the tissue and cross talk between cell types both ...
Roche, Rebecca
core +5 more sources
Identifying Influential Nodes in Complex Networks via Transformer with Multi-Scale Feature Fusion
Big Data and Cognitive ComputingIn complex networks, the identification of critical nodes is vital for optimizing information dissemination. Given the significant role of these nodes in network structures, researchers have proposed various identification methods.
Tingshuai Jiang +4 more
doaj +1 more source
Identifying influential spreaders by gravity model considering multi-characteristics of nodes
Scientific Reports, 2022 How to identify influential spreaders in complex networks is a topic of general interest in the field of network science. Therefore, it wins an increasing attention and many influential spreaders identification methods have been proposed so far.
Zhe Li, Xinyu Huang
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Finding Influential Nodes in Multiplex Networks Using a Memetic Algorithm
, 2021 Wang S, Liu J, Jin Y. Finding Influential Nodes in Multiplex Networks Using a Memetic Algorithm. IEEE Transactions on Cybernetics. 2021;51(2):900-912.In order to find the nodes with better propagation ability, a large body of studies on the influence ...
Liu, Jing +2 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source