Results 31 to 40 of about 314,289 (259)

Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies [PDF]

, 2014
The increased number of outbreaks of H5 and H7 LPAI and HPAI viruses in poultry has major public and animal health implications. The continuous rapid evolution of these subtypes and the emergence of new variants influence the ability to undertake ...
Rafat Rahman (16267478), Calogero Terregino, Temperton, Nigel J., Giovanni Cattoli, Calogero Terregino (4163389), Cattoli, Giovanni, Nigel J. Temperton, Eleonora Molesti, Giovanni Cattoli (52822), Terregino, Calogero, Nigel J Temperton (16261166), Rahman, R., Rafat Rahman, Eleonora Molesti (686215), Temperton, N.J., Rahman, Rafat, Edward Wright, Wright, Edward, Molesti, E., Wright, E., Edward Wright (4468198), Molesti, Eleonora, Terregino, C., Cattoli, G.   +23 more
core   +1 more source

Human Genes and Influenza [PDF]

The Journal of Infectious Diseases, 2008
Why some individuals resist infection or recover quickly, whereas others experience severe disease associated with infection, is a fundamental question that medicine has struggled to answer. Pathogens and host immune factors have been extensively investigated for many infectious diseases, to address these questions.
Samira Mubareka, Peter Palese
openaire   +1 more source

Overview of influenza surveillance in the United States [PDF]

The Epidemiology and Prevention Branch in the Influenza Division at CDC collects, compiles and analyzes information on influenza activity year-round in the United States and produces FluView, a weekly influenza surveillance report, and FluView ...

core   +8 more sources

Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir [PDF]

, 2014
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza ...
Dove, Brian K., Geoff Pearson, Kathryn A Ryan, Newman, Edmund, Wendy S Barclay, Bean, Thomas J., Carroll, Miles W., Miles W Carroll, Brian K Dove, Bassam Hallis, Edmund Newman, Easton, A. J. (Andrew J.), Marriott, Anthony C., Hallis, Bassam, Whittaker, Catherine J., Dimmock, N. J., Stuart Dowall, Silman, Nigel J., Barclay, Wendy S., Rayner, Emma, Bruce, Christine, Taylor, Irene, Jenna Plank, Andrew J Easton, Pearson, Geoff, Catherine J Whittaker, Nigel J Silman, Christine Bruce, Ryan, Kathryn A., Nigel J Dimmock, Irene Taylor, Emma Rayner, Plank, Jenna, Anthony C Marriott, Dowall, Stuart, Thomas J Bean   +35 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm

, 2013
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by ...
Xiao, Han, Killip, Marian Jane, Killip, Marian J., Stäheli, Peter, Staeheli, Peter, Randall, Richard Edward, Jackson, David   +6 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Swine influenza A virus subtype H1N2 in Sweden [PDF]

, 2012
The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent in pig populations worldwide. All scientific data point towards swine as the key host species when new human influenza pandemics arise.
Metreveli, Giorgi
core