Results 61 to 70 of about 9,115,931 (294)

Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

Emerging Infectious Diseases, 2019
In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling.
E. Takashita, Masataka Ichikawa, H. Morita, Rie Ogawa, Seiichiro Fujisaki, Masayuki Shirakura, H. Miura, Kazuya Nakamura, N. Kishida, Tomoko Kuwahara, H. Sugawara, Aya Sato, Miki Akimoto, K. Mitamura, Takashi Abe, M. Yamazaki, Shinji Watanabe, H. Hasegawa, T. Odagiri   +18 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Mortality due to respiratory diseases in the elderly after influenza vaccination campaigns in the Federal District, Brazil, 1996-2009 [PDF]

Jornal Brasileiro de Pneumologia, 2013
OBJECTIVE: To compare mortality rates due to respiratory diseases among elderly individuals residing in the Federal District of Brasília, Brazil, prior to and after the implementation of a national influenza vaccination campaign. METHODS: This was an
Francisca Magalhães Scoralick, Luciana Paganini Piazzolla, Liana Laura Pires, Cleudsom Neri, Wladimir Kummer de Paula   +4 more
doaj   +1 more source

ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells

Journal of Virology, 2019
Influenza virus is the etiological agent behind some of the most devastating infectious disease pandemics to date, and influenza outbreaks still pose a major threat to public health.
E. Staller, C. Sheppard, Peter J. Neasham, Bhakti Mistry, T. Peacock, Daniel H. Goldhill, Jason S. Long, W. Barclay   +7 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Safety and Immunogenicity of Betuvax-CoV-2, an RBD-Fc-Based SARS-CoV-2 Recombinant Vaccine: Preliminary Results of the First-in-Human, Randomized, Double-Blind, Placebo-Controlled Phase I/II Clinical Trial

Vaccines, 2023
COVID-19, being a life-threatening infection that evolves rapidly, remains a major public health concern calling for the development of vaccines with broad protection against different pathogenic strains and high immunogenicity.
Aleksandr V. Kudriavtsev, Anna V. Vakhrusheva, Nickolay A. Kryuchkov, Maria E. Frolova, Konstantin A. Blagodatskikh, Taras V. Ivanishin, Milana Djonovic, Ekaterina A. Romanovskaya-Romanko, Anton N. Kovalenko, Dmitry A. Lioznov, Tatiana G. Zubkova, Svetlana V. Teplykh, Rodion A. Oseshnyuk, Marina A. Stukova, Artur A. Isaev, Igor V. Krasilnikov   +15 more
doaj   +1 more source

Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 Hemagglutinin [PDF]

, 1983
The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 is presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA ...
Fiers, Walter, Huylebroeck, Danny, Min Jou, Willy, Van Rompuy, Ludo, Verhoeyen, Martine   +4 more
core   +3 more sources

Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

Nature Immunology, 2018
Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus during colonization are well studied in mice but ...
S. Jochems, Fernando Marcon, Beatriz F. Carniel, M. Holloway, E. Mitsi, Emma L Smith, J. Gritzfeld, Carla Solórzano, J. Reiné, S. Pojar, E. Nikolaou, E. German, A. Hyder-Wright, H. Hill, Caz Hales, Wouter A. A. de Steenhuijsen Piters, D. Bogaert, H. Adler, S. Zaidi, V. Connor, S. Gordon, J. Rylance, H. Nakaya, D. Ferreira   +23 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

EPIDEMIC RISE OF INFLUENZA IN ST. PETERSBURG IN JANUARY-MARCH 2018

Инфекция и иммунитет, 2018
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M. A. Bichurina, P. A. Petrova, A. A. Go, I. G. Chkhyndzheriya, L. V. Voloshchuk, M. M. Pisareva, N. I. Konovalova   +6 more
doaj   +1 more source