Results 81 to 90 of about 9,115,931 (294)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Antiviral responses by Swine primary bronchoepithelial cells are limited compared to human bronchoepithelial cells following influenza virus infection. [PDF]

PLoS ONE, 2013
Swine generate reassortant influenza viruses because they can be simultaneously infected with avian and human influenza; however, the features that restrict influenza reassortment in swine and human hosts are not fully understood.
Mary J Hauser, Daniel Dlugolenski, Marie R Culhane, David E Wentworth, S Mark Tompkins, Ralph A Tripp   +5 more
doaj   +1 more source

SARS-CoV-2 Variants in Lebanon: Evolution and Current Situation

Biology, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seen a worldwide spread since its emergence in 2019, including to Lebanon, where 534,968 confirmed cases (8% of the population) and 7569 deaths have been reported as of 14 May 2021 ...
Nancy Fayad, Walid Abi Habib, Ahmed Kandeil, Rabeh El-Shesheny, Mina Nabil Kamel, Youmna Mourad, Jacques Mokhbat, Ghazi Kayali, Jimi Goldstein, Jad Abdallah   +9 more
doaj   +1 more source

Proinflammatory cytokine response and viral replication in mouse bone marrow derived macrophages infected with influenza H1N1 and H5N1 viruses [PDF]

, 2012
The pathogenesis of human influenza H5N1 virus infection remains poorly understood and controversial. Cytokine dysregulation in human infection has been hypothesized to contribute to disease severity.
Chan, MCW, Chan, WY, Leung, CYH, Nicholls, JM, Peiris, JSM   +4 more
core   +1 more source

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

Nature Medicine, 2006
Avian influenza A (H5N1) viruses cause severe disease in humans, but the basis for their virulence remains unclear. In vitro and animal studies indicate that high and disseminated viral replication is important for disease pathogenesis.
Menno D. de Jong, Cameron P. Simmons, T. T. Thanh, V. M. Hien, G. J. Smith, Tran Nguyen Bich Chau, Dang Minh Hoang, Nguyen Van Vinh Chau, T. H. Khanh, Vo Cong Dong, P. Qui, Bach Van Cam, D. Ha, Y. Guan, J. S. M. Peiris, N. T. Chinh, T. T. Hien, J. Farrar   +17 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Vacinação contra o vírus influenza em gestantes: cobertura da vacinação e fatores associados

Einstein (São Paulo)
OBJETIVO: Descrever a cobertura vacinal de gestantes para influenza e fatores associados à recusa ou à aceitação da vacina. MÉTODOS: Estudo descritivo, prospectivo, que incluiu 300 puérperas atendidas no Hospital e Maternidade Santa Joana (SP).
Renato de Ávila Kfouri, Rosana Richtmann   +1 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. [PDF]

PLoS Pathogens, 2009
Transmission of avian influenza viruses from bird to human is a rare event even though avian influenza viruses infect the ciliated epithelium of human airways in vitro and ex vivo.
Margaret A Scull, Laura Gillim-Ross, Celia Santos, Kim L Roberts, Elena Bordonali, Kanta Subbarao, Wendy S Barclay, Raymond J Pickles   +7 more
doaj   +1 more source

Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses [PDF]

, 2018
Background With the recent discovery of novel H17N10 and H18N11 influenza viral RNA in bats and report on high frequency of avian H9 seroconversion in a species of free ranging bats, an important issue to address is the extent bats are susceptible to ...
AC Banyard, AGD Bean, B Hu, CR Gaush, D Bernasconi, D Dlugolenski, DS Poole, EA Govorkova, GS Freidl, I Eckerle, I Ramos, Isabella Eckerle, J Stevens, J Xie, K Shuai, Kin-Chow Chang, M Delgado-Ortega, M Hoffman, M Juozapaitis, O Planz, R Pinto, RK Nelli, RK Nelli, S Matikainen, S Panzer, S Tong, SH Seo, SJ Gamblin, SV Kuchipudi, Tessa Slater, V Sandekian, W Weis, Y Wu   +32 more
core   +3 more sources