Results 81 to 90 of about 325,943 (270)
Эпидемиология и вакцинопрофилактика, 2016 The analysis of the spatial-temporal distribution of influenza data weekly to WHO data in the summer of 2015 in the countries of the Southern and Northern hemispheres It is shown that in the Southern hemisphere registered a moderate influenza epidemics ...
O. L. Kiselev +3 more
doaj +1 more source
Epistatically interacting substitutions are enriched during adaptive protein evolution. [PDF]
PLoS Genetics, 2014 Most experimental studies of epistasis in evolution have focused on adaptive changes-but adaptation accounts for only a portion of total evolutionary change. Are the patterns of epistasis during adaptation representative of evolution more broadly?
Lizhi Ian Gong, Jesse D Bloom
doaj +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Avian influenza virus and human: pandemic concern and threat? [PDF]
Reviews in Clinical Medicine, 2016 Type A influenza viruses causes infections in human and animals, especially in birds. Wild aquatic birds are the natural hosts for all known influenza type A viruses. Avian type viruses are divided into two groups: highly pathogenic avian influenza (HPAI)
Mohammad Derakhshan
doaj +1 more source
Computer-assisted vaccine design [PDF]
arXiv, 2009 We define a new parameter to quantify the antigenic distance between two H3N2 influenza strains: we use this parameter to measure antigenic distance between circulating H3N2 strains and the closest vaccine component of the influenza vaccine. For the data between 1971 and 2004, the measure of antigenic distance correlates better with efficacy in humans ...
arxiv
Explaining the geographic origins of seasonal influenza A (H3N2) [PDF]
arXiv, 2016 Most antigenically novel and evolutionarily successful strains of seasonal influenza A (H3N2) originate in East, South, and Southeast Asia. To understand this pattern, we simulated the ecological and evolutionary dynamics of influenza in a host metapopulation representing the temperate north, tropics, and temperate south.
arxiv
Seasonality in the migration and establishment of H3N2 Influenza lineages with epidemic growth and decline [PDF]
, 2014 Background: Influenza A/H3N2 has been circulating in humans since 1968, causing considerable morbidity and mortality. Although H3N2 incidence is highly seasonal, how such seasonality contributes to global phylogeographic migration dynamics has not yet been established. Results: Incorporating seasonally varying migration rates improves the modeling of
arxiv +1 more source
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Qualitative evaluation of a molecular point-of-care testing study for influenza in UK primary care
BJGP OpenBackground: Influenza contributes to the surge in winter infections and the consequent winter pressures on the health service. Molecular point-of-care testing (POCT) for influenza may improve patient management by providing rapid and accurate clinical ...
Charis Xuan Xie +12 more
doaj +1 more source
On the use of multiple compartment epidemiological models to describe the dynamics of influenza in Europe [PDF]
arXiv, 2019 We develop a multiple compartment Susceptible-Infected-Recovered (SIR) model to analyze the spread of several infectious diseases through different geographic areas. Additionally, we propose a data-quality sensitive optimization framework for fitting this model to observed data.
arxiv