Results 1 to 10 of about 3,336,304 (397)

Integrating influenza antigenic dynamics with molecular evolution [PDF]

arXiv, 2013
Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains using the hemagglutination inhibition (HI) assay.
Abed, Ansaldi, Ansaldi, Barr, Barr, Bedford, Bedford, Bogner, Borodin, Cai, Centers for Disease Control and Prevention, Chakraverty, Chakraverty, Cox, Cox, Daniels, Daum, Daum, Donatelli, Drummond, Edgar, Ferguson, Fitch, Gog, Goldstein, Gust, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hensley, Hirst, Kanegae, Kendal, Klimov, Koel, Lemey, Li, Lin, Lin, Lin, Lin, Matsuzaki, McCauley, McCauley, McCauley, McCauley, McCauley, McDonald, Muyanga, Nakagawa, Nakajima, Nakajima, Nakajima, Nelson, Nerome, Oh, Osterholm, Pagel, Pereira, Puzelli, Pybus, Raymond, Rota, Russell, Shapiro, Shaw, Smith, Squires, Stevens, Webster, Wiley, World Health Organization, Xu   +83 more
arxiv   +7 more sources

STUDIES ON THE VIRUS OF INFLUENZA [PDF]

Journal of Experimental Medicine, 1936
1. Evidence is presented indicating the presence of a filtrable virus in the nasopharyngeal secretions of individuals suffering from influenza. 2. An attempt to transfer influenza from one human being to another by means of filtered nasopharyngeal washings resulted in the production in the inoculated volunteer of a common cold.
A. R. Dochez, K. C. Mills, Yale Kneeland
openalex   +5 more sources

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

arXiv, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like genealogical tree. Here, we use a large-scale individual-based model to show that evolution in a Euclidean
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
arxiv   +8 more sources

Identification of Novel and Efficacious Chemical Compounds that Disturb Influenza A Virus Entry in vitro

Frontiers in Cellular and Infection Microbiology, 2017
Influenza A virus is a negative RNA stranded virus of the family Orthomyxoviridae, and represents a major public health threat, compounding existing disease conditions.
Hany Khalil, Tamer El Malah, Ahmed I. Abd El Maksoud, Ibrahim El Halfawy, Ahmed A. El Rashedy, Mahmoud El Hefnawy   +5 more
doaj   +2 more sources

Influenza virus in human exhaled breath: an observational study. [PDF]

PLoS ONE, 2008
Recent studies suggest that humans exhale fine particles during tidal breathing but little is known of their composition, particularly during infection.We conducted a study of influenza infected patients to characterize influenza virus and particle ...
Patricia Fabian, James J McDevitt, Wesley H DeHaan, Rita O P Fung, Benjamin J Cowling, Kwok Hung Chan, Gabriel M Leung, Donald K Milton   +7 more
doaj   +4 more sources

Epidemiological and Virological Characterization of Influenza B Virus Infections. [PDF]

PLoS ONE, 2016
While influenza A viruses comprise a heterogeneous group of clinically relevant influenza viruses, influenza B viruses form a more homogeneous cluster, divided mainly into two lineages: Victoria and Yamagata.
Sivan Sharabi, Yaron Drori, Michal Micheli, Nehemya Friedman, Sara Orzitzer, Ravit Bassal, Aharona Glatman-Freedman, Tamar Shohat, Ella Mendelson, Musa Hindiyeh, Michal Mandelboim   +10 more
doaj   +4 more sources

Chicken cyclophilin A is an inhibitory factor to influenza virus replication [PDF]

Virology Journal, 2010
Background The importance of enhancing influenza resistance in domestic flocks is quite clear both scientifically and economically. Chicken is very susceptible to influenza virus.
Sun Lei, Liu Xiaoling, Meng Shanshan, Xu Chongfeng, Liu Wenjun   +4 more
doaj   +5 more sources

Memory B cells and CD8⁺ lymphocytes do not control seasonal influenza A virus replication after homologous re-challenge of rhesus macaques. [PDF]

, 2011
This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental ...
Carroll, Timothy D, Fritts, Linda, Matzinger, Shannon R, McChesney, Michael B, Miller, Christopher J   +4 more
core   +17 more sources

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication [PDF]

, 2017
Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility.
Chen, Xiang, Chen, Zhijian J, Diamond, Michael S, Fontoura, Beatriz M. A., Garcia-Sastre, Adolfo, Krammer, Florian, Kuss-Duerkop, Sharon K, Mata, Miguel A, Mena, Ignacio, Metreveli, Giorgi, Munoz-Moreno, Raquel, Sakthivel, Ramanavelan, Wang, Juan, White, Kris   +13 more
core   +22 more sources

Influenza virus [PDF]

Medicina, 2007
Every year, especially during the cold season, many people catch an acute respiratory disease, namely flu. It is easy to catch this disease; therefore, it spreads very rapidly and often becomes an epidemic or a global pandemic. Airway inflammation and other body ailments, which form in a very short period, torment the patient several weeks. After that,
Juozapaitis, Mindaugas, Antoniukas, Linas   +1 more
openaire   +5 more sources