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Influenza A viruses (IAV) and influenza B viruses (IBV) cause significant morbidity and mortality during seasonal outbreaks. Cleavage of the viral surface glycoprotein hemagglutinin (HA) by host proteases is a prerequisite for membrane fusion and ...
H. Limburg+13 more
semanticscholar +1 more source
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract infections that produce a wide spectrum of clinical disease severity in humans.
T. Flerlage+4 more
semanticscholar +1 more source
Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine, Southeast Mexico
The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe evolution of swine influenza A viruses in Mexico and
Martha I. Nelson+9 more
doaj +1 more source
Direct RNA Sequencing of the Coding Complete Influenza A Virus Genome
For the first time, a coding complete genome of an RNA virus has been sequenced in its original form. Previously, RNA was sequenced by the chemical degradation of radiolabeled RNA, a difficult method that produced only short sequences.
Matthew W. Keller+9 more
semanticscholar +1 more source
Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites
Influenza A virus has an eight-partite RNA genome that during viral assembly forms a complex containing one copy of each RNA. Genome assembly is a selective process driven by RNA-RNA interactions and is hypothesized to lead to discrete punctate ...
Marta Alenquer+5 more
semanticscholar +1 more source
Influenza pathogenesis: mechanisms of modulation by agent proteins
Modern concepts of the influence of the proteins from viruses-etiological agents of flu – Influenzavirus A, B and C (Orthomyxoviridae) – on the development of different elements of the main disease pathogenesis are analyzed in the review.
M. Yu. Shchelkanov+7 more
doaj +1 more source
Influenza and other acute respiratory viral infections are the most common infectious diseases of our time, causing a significant harm to human health as well as great economic damage.
N. G. Klivleyeva+9 more
doaj +1 more source
Influenza and memory T cells : how to awake the force [PDF]
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen+12 more
core +3 more sources
Development of DNA-Biochip for Identification of Influenza A Virus Subtypes
Developed was the DNA-biochip to identify subtypes of influenza A virus, pathogenic for humans. Microchip was capable of detecting H1, H3, H5-subtypes of hemagglutinin (including H1-subtype of pandemic A/H1N1(2009) influenza virus ) and neuraminidase ...
A. N. Shikov+8 more
doaj +1 more source
Drug resistance in influenza A virus: the epidemiology and management
Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual influenza epidemics in humans.
M. Hussain+4 more
semanticscholar +1 more source