Results 11 to 20 of about 114,208,131 (218)

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules. [PDF]

PLoS ONE, 2011
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
Anna Hultberg, Nigel J Temperton, Valérie Rosseels, Mireille Koenders, Maria Gonzalez-Pajuelo, Bert Schepens, Lorena Itatí Ibañez, Peter Vanlandschoot, Joris Schillemans, Michael Saunders, Robin A Weiss, Xavier Saelens, José A Melero, C Theo Verrips, Steven Van Gucht, Hans J de Haard   +15 more
doaj   +2 more sources

Contribution of E190D and Q226H Mutations in HA to the Receptor-Binding Profile of D1.1 Genotype H5N1 Viruses. [PDF]

Influenza Other Respir Viruses
ABSTRACT A 2024 human HPAI H5N1 case in British Columbia showed mixed viral populations containing HA‐190D (28%) and HA‐226H (35%) variants in tracheal aspirate sequencing. In this study, solid‐phase binding assay and molecular docking were used to evaluate the contribution of HA‐E190D/Q226H mutations to the viral receptor profiles.
Fang Y, Yang L, Zou S, Liu L, Zhu W, Wang D.   +5 more
europepmc   +2 more sources

Avian Influenza Virus A Subtype H5N1

UMI Medical Journal, 2023
Latar Belakang: Avian influenza adalah infeksi virus menular yang menyerang unggas, hewan, dan manusia di seluruh dunia. Sebagian besar infeksi pada manusia disebabkan oleh virus influenza tipe A dan B, sedangkan unggas hanya terinfeksi oleh influenza tipe A. Isi: Masa inkubasi umumnya 2 sampai 7 hari, tapi bisa selama 8 sampai 9 hari.
Erza Anugrah, M. Almutaali
openaire   +1 more source

Serological Surveillance of Avian Influenza Virus Exposure Using Paired Sera Among Occupational Contacts in Taiwan, January-September 2025. [PDF]

Influenza Other Respir Viruses
ABSTRACT In 2025, Taiwan implemented paired sera surveillance among occupational contacts of avian influenza viruses (AIVs). Of 122 contacts analyzed, 117 (95.9%) remained asymptomatic with high personal protective equipment compliance (91.8%). No seroconversion was detected against AIV A(H5N2) clade 2.3.4.4b. These findings suggest a low risk of human
Lin CY, Tsou TP, Chu PW, Yang SE, Yu IL, Li YT, Liu MT, Chih YC.   +7 more
europepmc   +2 more sources

Immunogenicity of a Multi-Epitope Influenza Composite Peptide Vaccine Targeting Human, Swine, and Avian Viruses: Advancing Pandemic Preparedness. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background The emergence of novel reassortant influenza A virus strains and zoonotic transmission to the human population is a critical factor in the development of a global pandemic, as exemplified by the 2009 swine flu pandemic and the ongoing threat of an H5N1 avian flu pandemic.
Rikhi N, Sei CJ, Fraser KA, Muema K, Assiaw-Dufu A, Schuman RF, Fischer GW.   +6 more
europepmc   +2 more sources

Determinants of Antiviral Effectiveness in Influenza Virus A Subtype H5N1 [PDF]

Journal of Infectious Diseases, 2012
Oseltamivir is widely used as treatment for influenza virus A subtype H5N1 (hereafter, "H5N1") infection but, like any intervention, is not always effective.We used Avian Influenza Registry data from 10 countries to examine the risk of death in 215 patients with confirmed H5N1 infection who were treated with oseltamivir, according to viral clade, age ...
Dreyer, Nancy A., Zaman, Mukhtiar, Hanshaoworakul, Wanna, Chan, Paul K. S., Gasimov, Viktor, Toovey, Stephen, Lee, Nelson, Oner, Ahmet Faik, Tsang, Owen, Phommasack, Bounlay, Coker, Richard, Adisasmito, Wiku, Touch, Sok, Bamgboye, Ebun, Swenson, Anna, DOĞAN, Nazim   +15 more
openaire   +4 more sources

Avian influenza overview March-May 2026. [PDF]

EFSA J
Abstract Between 28 February and 4 June 2026, 949 highly pathogenic avian influenza (HPAI) A(H5) virus detections were reported in domestic (186) and wild (763) birds in 30 countries in Europe. The downward trend in the number of detections observed at the end of the previous reporting period continued and is expected to persist throughout the summer ...
European Food Safety Authority (EFSA), European Centre for Disease Prevention and Control (ECDC), European Union Reference Laboratory for Avian Influenza (EURL), Buczkowski H, Ducatez M, Fusaro A, Gonzales JL, Kuiken T, Mirinavičiūtė G, Ståhl K, Staubach C, Svartström O, Terregino C, Willgert K, Alarcón E, Kohnle L.   +15 more
europepmc   +2 more sources

Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype [PDF]

mBio, 2012
In their recent paper, Peter Palese and Taia T. Wang proposed a hypothesis to explain how an older circulating subtype of influenza A virus is replaced with a novel subtype (1). They and others also published experimental evidence supporting their hypothesis on the extinction of seasonal H1N1 viruses by the 2009 pandemic H1N1 viruses (2). Although they
Masanori Terajima, Jenny Aurielle B. Babon, Francis A. Ennis   +2 more
openaire   +3 more sources

Generation and characterisation of monoclonal antibodies against influenza virus A, subtype H5N1 [PDF]

Journal of Virological Methods, 2011
The emergence of highly pathogenic avian influenza A virus (HPAIV) subtype H5N1 in 1997 has since resulted in large outbreaks in poultry and in transmission from poultry to humans, mostly in southeast Asia, but also in several European countries. Effective diagnosis and control measures are essential for the management of HPAIV infections. To develop a
Linke, Sonja, Neubauer, Katrin, Dorner, Martin, Dorner, Brigitte, Pauli, Georg, Schweiger, Brunhilde   +5 more
openaire   +3 more sources

Latex Agglutination Test for Monitoring Antibodies to Avian Influenza Virus Subtype H5N1 [PDF]

Journal of Clinical Microbiology, 2005
ABSTRACT A latex agglutination test (LAT) based on polystyrene beads sensitized with inactivated avian influenza virus H5N1 particles was developed. Compared with the hemagglutination inhibition test, the sensitivity and specificity of the LAT were 88.8 and 97.6%, respectively, in detecting 830 serum samples from vaccinated chickens. The test
Xiaojuan, Xu, Meilin, Jin, Zhengjun, Yu, Hongchao, Li, Dexin, Qiu, Yadi, Tan, Huanchun, Chen   +6 more
openaire   +2 more sources