Results 81 to 90 of about 367,688 (317)

Influenza A nucleoprotein binding sites for antivirals: current research and future potential [PDF]

, 2014
This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2014. The
Kukol, A, Kukol, A, Patel, H., Patel, H.
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source

Enhancement of influenza virus infections by secalonic acid D.

Environmental Health Perspectives, 1986
Secalonic acid D (SAD), a hepatotoxic, teratogenic, and slightly mutagenic metabolite of Penicillium oxalicum has been identified as a natural contaminant of grain dust. Secalonic acid D was administered intraperitoneally to male ICR mice that were exposed to influenza virus aerosols 5 days earlier.
D S, Fleischhacker, T G, Akers, S P, Katz, M S, Palmgren   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Influenza D Virus Circulation in Cattle and Swine, Luxembourg, 2012–2016

Emerging Infectious Diseases, 2018
We detected antibodies against influenza D in 80.2% of the cattle sampled in Luxembourg in 2016, suggesting widespread virus circulation throughout the country.
Chantal J. Snoeck, Justine Oliva, Maude Pauly, Serge Losch, Félix Wildschutz, Claude P. Muller, Judith M. Hübschen, Mariette F. Ducatez   +7 more
doaj   +1 more source

Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus : studies in the pig model of influenza [PDF]

, 2015
Pigs are natural hosts for the same influenza virus subtypes as humans and are a valuable model for cross-protection studies with influenza. In this study, we have used the pig model to examine the extent of virological protection between a) the 2009 ...
A Krumbholz, A Lavenu, AC Lowen, AI Karasin, AR Vleeschauwer De, AS Monto, B Brandenburg, B Manicassamy, B Srivastava, CD O’Donnell, CD O’Donnell, CS Kyriakis, CS Kyriakis, DM Skowronski, ED Kilbourne, G Simon, GA Landolt, GG Brownlee, I Skountzou, IH Brown, JC Kash, JH Kreijtz, JL Schulman, K Hoschler, K Reeth Van, K Reeth Van, K Reeth Van, K Reeth Van, K Tamura, Karl De hert, KL Laurie, Kristien Van Reeth, L Campitelli, M Khatri, M Pensaert, M Retamal, M Strengell, MA Marco De, MI Nelson, MJ Sylte, ML Hillaire, MR Castrucci, MR Castrucci, MR Sandbulte, N Busquets, NM Bouvier, PM Colman, PP Heinen, RA Perera, RA Yetter, RJ Garten, S Liang, SL Epstein, SM Brookes, T Sonoguchi, TM Straight, Y Qiu, Y Qiu, Yu Qiu   +58 more
core   +6 more sources

Novel Influenza D virus: Epidemiology, pathology, evolution and biological characteristics [PDF]

Virulence, 2017
In 2011, a new virus was isolated from pigs with influenza-like symptoms and subsequently also from cattle, which are the main reservoir of the virus. It is similar to Influenza C virus (ICV), a (predominantly) human pathogen, causing respiratory disease in children. Since the virus is unable to reassort with ICV (and based on several other criteria as
Shuo, Su, Xinliang, Fu, Gairu, Li, Fiona, Kerlin, Michael, Veit   +4 more
openaire   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Influenza D Virus in Animal Species in Guangdong Province, Southern China

Emerging Infectious Diseases, 2017
Molecular tests revealed influenza D viruses of D/OK lineage widely circulating in farmed animal species in Guangdong Province, southern China. In particular, we found high levels of influenza D virus infection in goats and pigs.
Shao-Lun Zhai, He Zhang, Sheng-Nan Chen, Xia Zhou, Tao Lin, Runxia Liu, Dian-Hong Lv, Xiao-Hui Wen, Wen-Kang Wei, Dan Wang, Feng Li   +10 more
doaj   +1 more source