Results 91 to 100 of about 229,517 (308)

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

The intentions to get vaccinated against influenza and actual vaccine uptake among diabetic patients in Ningbo, China: identifying motivators and barriers

Human Vaccines & Immunotherapeutics, 2021
Background: Health authorities recommend influenza vaccination to diabetic patients. Nevertheless, the vaccination coverage of adults was low in China.
Lixia Ye, Ting Fang, Jun Cui, Guanghui Zhu, Rui Ma, Yexiang Sun, Pingping Li, Hui Li, Hongjun Dong, Guozhang Xu   +9 more
doaj   +1 more source

Cochrane acute respiratory infections group's stakeholder engagement project identified systematic review priority areas [PDF]

, 2018
Objective: Cochrane acute respiratory infections (ARIs) group conducts systematic reviews of the evidence for treatment and prevention of ARIs. We report the results of a prioritization project, aiming to identify highest priority systematic review ...
Clark, Justin, Del Mar, Chris, Dooley, Liz, Jones, Ann, Jones, Mark, Scott, Anna Mae   +5 more
core   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Increasing influenza vaccination rates in solid organ transplant recipients in an outpatient transplant centre

Proceedings of Singapore Healthcare, 2020
Although influenza can lead to significant morbidity and mortality in solid organ transplant recipients, its vaccination rate among solid organ transplant recipients remains low.
Yan Ting Yeo, Jielin Song, Eleanor Gek Theng Ng, Nuraini Lee Binte Ismail Lee, Terence Yi Shern Kee, Chee Kiat Tan, Petrina Yuen Wai Fan, Puay Hoon Lee   +7 more
doaj   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Review of seasonal influenza vaccination in the Eastern Mediterranean Region: Policies, use and barriers

Journal of Infection and Public Health, 2019
Vaccination is the main control measure for influenza and its severe complications. To better understand the influenza vaccination situation in the Eastern Mediterranean Region, we conducted an extensive review of literature published between 2006 and ...
Hassan Zaraket, Nada Melhem, Mamunur Malik, Wasiq M. Khan, Ghassan Dbaibo, Abdinasir Abubakar   +5 more
doaj   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Government livelihood project - free influenza vaccination for the older population in China: the example of Zhejiang Province

Frontiers in Public Health
Influenza vaccination is an effective measure to prevent and control influenza, and countries worldwide consider older people a key recommended population for influenza vaccination.
Xiaoxiao Wang, Xiaoxiao Wang, Wei Jiang, Zhao Yu, Weiping Jiang, Xiaowei Zhu, Zhen Wang, Jimin Sun, Jimin Sun, Hangjie Zhang, Hangjie Zhang   +10 more
doaj   +1 more source

Estimates of influenza vaccine effectiveness in primary care in Scotland vary with clinical or laboratory endpoint and method : experience across the 2010/11 season [PDF]

, 2013
Aim: This study examines estimation of seasonal influenza vaccine effectiveness (VE) for a cohort of patients attending general practice in Scotland in 2010/11.
Kavanagh, Kimberley, McMenamin, Jim, Robertson, Charles   +2 more
core   +3 more sources