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Pandemic Influenza Vaccines [PDF]
, 2009 Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ from seasonal vaccines to influenza virus, which are updated annually in spring to incorporate the latest circulating viruses, and are then ...
Lauren J. DiMenna, Hildegund C. J. Ertl
openaire +3 more sources
Nature Communications, 2019 Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to ...
S. Khurana +7 more
semanticscholar +1 more source
Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Advanced Science, EarlyView.Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren +19 more
wiley +1 more source
Frontiers in Public HealthIntroductionInfluenza vaccination is one of the most important strategies for preventing influenza. However, the influenza vaccination rate in China remains low.
Yun Zhang, Hongfa Yi
doaj +1 more source
Journal of Infectious Diseases, 2019 For 50 years it has been known that antibodies to neuraminidase (NA) protect against infection during seasonal and pandemic influenza outbreaks. However, NA is largely ignored in the formulation and standardization of our current influenza vaccines ...
M. Eichelberger, A. Monto
semanticscholar +1 more source
Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines
Vaccines, 2020 Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health.
Ekramy E. Sayedahmed +4 more
semanticscholar +1 more source
Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B
Advanced Science, EarlyView.Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang +8 more
wiley +1 more source
Challenges in estimating influenza vaccine effectiveness
Expert Review of Vaccines, 2019 Introduction: Influenza vaccination is regarded as the most effective way to prevent influenza infection. Due to the rapid genetic changes that influenza viruses undergo, seasonal influenza vaccines must be reformulated and re-administered annually ...
K. Ainslie, M. Haber, W. Orenstein
semanticscholar +1 more source
Advanced Science, EarlyView.This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong +12 more
wiley +1 more source
Pharmaceutics, 2019 It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing ...
Min-Chul Kim +9 more
doaj +1 more source