Results 131 to 140 of about 282,997 (350)

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Influenza vaccine programs for children in low- and middle-income countries: current status and way forward

Expert Review of Vaccines, 2019
Introduction: Influenza vaccines are safe and effective, yet they are infrequently used in low- and middle-income countries (LMICs). Areas covered: We examine influenza vaccine programs for children from within a framework of new vaccine adoption in ...
Justin R Ortiz, Kathleen M Neuzil
doaj   +1 more source

Understanding Caregiver Factors Influencing Childhood Influenza Vaccination [PDF]

, 2012
Influenza is a contagious disease that affects approximately 30% to 40% of American children yearly, and all children 18 and under are recommended to be vaccinated.
Avola, Gianelle M., Lyon, Jennifer A.
core   +1 more source

MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection

Advanced Science, EarlyView.
MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani, Luca Capelli, Denise Di Lena, Alejandro Chamorro‐Garcia, Rudy Ippodrino, Alessandro Porchetta, Alessandro Bertucci   +6 more
wiley   +1 more source

Anti-influenza antibody level after vaccination in north of Iran [PDF]

, 2009
Objective:Influenza is a highly transmitted disease and about 10% of the world's population is affected by this disease annually. The aim of this research was to study the variation of serum antibody levels among subjects who had already been vaccinated ...
Abbasi, A., Mansourian, A.R., Moradi, A., Rajaei, S.   +3 more
core  

Mathematical modeling for estimating influenza vaccine efficacy: A case study of the Valencian Community, Spain.

Infectious Disease Modelling
Vaccine efficacy and its quantification is a crucial concept for the proper design of public health vaccination policies. In this work we proposed a mathematical model to estimate the efficacy of the influenza vaccine in a real-word scenario.
Carlos Andreu-Vilarroig, Rafael J. Villanueva, Gilberto González-Parra   +2 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Influenza and the implications of a pandemic for Malta [PDF]

, 2005
An influenza pandemic is inevitable and recent reports from Southeast Asia on avian influenza viruses infecting humans have served to fuel worries that a new pandemic is near.
Farrugia, Ryan, Melillo Fenech, Tanya, Spiteri, Gianfranco   +2 more
core  

Factors affecting influenza vaccine uptake among health care workers [PDF]

, 2005
Frank O’Reilly, G. W. Cran, A. B. Stevens   +2 more
openalex   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source