Results 61 to 70 of about 266,103 (305)

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Estimates of influenza vaccine effectiveness in primary care in Scotland vary with clinical or laboratory endpoint and method : experience across the 2010/11 season [PDF]

, 2013
Aim: This study examines estimation of seasonal influenza vaccine effectiveness (VE) for a cohort of patients attending general practice in Scotland in 2010/11.
Kavanagh, Kimberley, McMenamin, Jim, Robertson, Charles   +2 more
core   +3 more sources

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Knowledge, attitudes, barriers and uptake rate of influenza virus vaccine among adults with chronic diseases in Jordan: a multicentric cross-sectional study

Frontiers in Public Health
BackgroundSeasonal Influenza is a major cause of morbidity and mortality worldwide. Despite the well-established preventive role of the influenza vaccine particularly for patients at high risk, influenza vaccine uptake remains suboptimal. In Jordan, data
Munir Abu-Helalah, Munir Abu-Helalah, Tarek Gharibeh, Mohammad Al-Hanaktah, Islam Khatatbeh, Fadi Batarseh, Amro Asfour, Omar Okkeh, Abdallah Dalal, Ahmad Alhendi, Huthaifa Ababneh   +10 more
doaj   +1 more source

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment [PDF]

, 2014
There is an urgent need for rapid methods to develop vaccines in response to emerging viral pathogens. Whole inactivated virus (WIV) vaccines represent an ideal strategy for this purpose; however, a universal method for producing safe and immunogenic ...
Achilefu, Samuel, Chen, Alexander, Donthi, Nisha, Hsieh, Wen-Han, Hung, Chien-Fu, Knoff, Jayne, La, Victor, Li, Yen-Der, Tsen, Kong-Thon, Tsen, Shaw-Wei David, Wu, Tzyy-Choou   +10 more
core   +2 more sources

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Acceptance of influenza vaccination and associated factors among teachers in China: A cross-sectional study based on health belief model

Human Vaccines & Immunotherapeutics, 2023
Teachers played an important role on the transmission of influenza in schools and communities. The study aims to investigate the influenza vaccination coverage and the factors determining flu vaccination acceptance among teachers in Hangzhou, China.
Wenwen Gu, Yan Liu, Qinghua Chen, Jun Wang, Xinren Che, Jian Du, Xiaoping Zhang, Yuyang Xu, Xuechao Zhang, Wei Jiang, Jing Wang, Qixin Xie, Zhaojun Lu, Yingying Yang, Lintao Gu, Junfang Chen   +15 more
doaj   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Sequencing and Phylogenetic Analysis of NS Gene of Two Isolates of H9N2 Influenza Virus and The Growth Characteristics of the Virus on A549 Cells

مجله دانشکده پزشکی اصفهان, 2014
مقدمه: ویروس‌ آنفلوانزای پرندگان تحت تیپ 2N9H در طول دو دهه‌ی گذشته در آسیا به صورت پانزوتیک در آمده است. این ویروس، علاوه بر ایجاد بیماری در طیور پرورشی، چندین مورد ابتلای انسانی در آسیا را سبب شده است.
Shahla Shahsavandi, Abbas Ahmadi-Vasmehjani, Mohammad Shayestehpour, Kaweh Sadeghi, Mohammad Majid Ebrahimi, Hadi Fazel   +5 more
doaj  

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source