Results 71 to 80 of about 635,953 (258)

Knowledge and Attitudes of Adult Diabetic Patients Attending Primary Health Care in Bahrain about Seasonal Influenza and Influenza Vaccination - A Cross-Sectional Study

Journal of the Bahrain Medical Society
Introduction: Influenza is a highly contagious respiratory viral illness that is vaccine-preventable and occurs seasonally. While most cases present with mild respiratory symptoms, influenza can lead to severe complications in vulnerable ...
Fatema Ali Mohamed Alekri, Maryam Majeed Ahmed   +1 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial [PDF]

, 2006
Objective To determine whether vaccination of care home staff against influenza indirectly protects residents.Design Pair matched cluster randomised controlled trial.Setting Large private chain of UK care homes during the winters of 2003-4 and 2004-5 ...
Murad, S, Smedley, J, Hayward, AC, Wetten, S, Harling, R, Watson, JM, Johnson, AM, Munro, S   +7 more
core  

A Review of the 2016-2017 Flu Season: Guidelines, Costs, and Barriers

Online Journal of Rural Nursing and Health Care, 2017
In the United States (US), about 50,000 influenza-related deaths occur annually (Centers for Medicaid and Medicare Services [CMS], 2014).  The most important preventive measure for the influenza virus is for people to obtain the influenza vaccine (Varsha
Simone Chinnis, James Sterrett, Richetta Deas, Whitney Smith, Ruth Conner   +4 more
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Influenza vaccination uptake among people aged over 85 years: an audit of primary care practice in the UK [PDF]

, 2014
Public health research and national guidelines have advocated for seasonal influenza vaccination in the elderly. General practice has established itself as an ideal setting for the safe administration and monitoring of vaccines.1 Due to waning immune
Arnott, ND, Fitchett, JR
core  

Influenza virus circulation and vaccine effectiveness during June 2021–May 2023 in Thailand

Vaccine: X
Thai Ministry of Public Health recommends influenza vaccination for certain risk groups. We evaluated 2023 Southern Hemisphere influenza vaccine effectiveness against medically attended influenza using surveillance data from nine Thai hospitals and a ...
Kriengkrai Prasert, Prabda Praphasiri, Sutthichai Nakphook, Darunee Ditsungnoen, Patranuch Sapchookul, Kanlaya Sornwong, Suriya Naosri, Pilailuk Akkapaiboon Okada, Piyarat Suntarattiwong, Tawee Chotpitayasunondh, Martha P. Montgomery, William W. Davis, Chakrarat Pittayawonganon   +12 more
doaj   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

The drivers of influenza vaccination in adults: Insights from a national Australian survey

Vaccine: X
Influenza vaccination coverage is suboptimal in the Australian adult population. While coverage data is used to monitor uptake, at present, there is no systematic data collection on the behavioural and social drivers of vaccination.
Maria Christou-Ergos, Majdi M. Sabahelzain, Maryke Steffens, Jessica Kaufman, Katarzyna T. Bolsewicz, Margie Danchin, Julie Leask   +6 more
doaj   +1 more source

Seasonal influenza vaccine in immunocompromised persons

Human Vaccines & Immunotherapeutics, 2018
Immunocompromised persons are at high risk of complications from influenza infection. This population includes those with solid organ transplants, hematopoietic stem cell transplants, solid cancers and hematologic malignancy as well as those with ...
Mohammad Bosaeed, Deepali Kumar
doaj   +1 more source