Results 151 to 160 of about 968,734 (398)
Advanced Science, EarlyView.This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen +12 more
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Research Progress of Universal Influenza Vaccine
VaccinesInfluenza viruses continue to undergo antigenic drift and shift, resulting in the need to update existing vaccines annually. Therefore, the development of a universal influenza vaccine has become an urgent global need. This paper reviews the functions of
Liangliang Wang +7 more
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M2e-Based Universal Influenza A Vaccines
Vaccines, 2015 The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease.
Lei Deng +3 more
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Influenza vaccines and immunopathology [PDF]
Expert Review of Vaccines, 2012 “…the concern over immunopathology resulting from T-cell responses to nucleoprotein or other conserved antigens in the absence of neutralizing antibodies in humans can be narrowed to high-dose infections with some pandemic viruses, although both in 1918 and 2009, there is evidence that T-cell responses were more likely to be responsible for protection ...
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The use of cell-mediated immunity for the evaluation of influenza vaccines: an upcoming necessity
Human Vaccines & Immunotherapeutics, 2019 Influenza vaccines are a fundamental tool for preventing the disease and reducing its consequences, particularly in specific high-risk groups. In order to be licensed, influenza vaccines have to meet strict criteria established by European Medicines ...
Elena Gianchecchi +2 more
semanticscholar +1 more source
B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns
Advanced Science, EarlyView.B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang +16 more
wiley +1 more source
Future epidemiological and economic impacts of universal influenza vaccines
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Diminished efficacy of influenza vaccines has fueled research and funding for a broadly protective vaccine. NIAID recently proposed at least 75% efficacy against symptomatic influenza as a key criterion for a universal vaccine.
P. Sah +6 more
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Advanced Science, EarlyView.Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei +12 more
wiley +1 more source
VaccinesThis study assessed IgG levels to influenza/pertussis and neutralizing antibody (Nab) responses of COVID-19 vaccines in blood of pregnant women following immunization with pertussis (Tdap), influenza, and COVID-19 vaccines.
Wei-Chun Chen +7 more
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ADJUVANTS IN IMMUNIZATION WITH INFLUENZA VIRUS VACCINES [PDF]
, 1944 William F. Friedewald
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