Results 251 to 260 of about 859,419 (358)

Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A71 Challenge

open access: yesPhytotherapy Research, EarlyView.
Pterostilbene (Pte) binds to the VP1 hydrophobic pocket of enteroviruses, stabilizing the viral capsid and preventing uncoating and RNA release. In vitro, Pte inactivates virions and impairs viral attachment, entry, and replication. In vivo, oral administration of Pte in hSCARB2‐transgenic mice reduces clinical symptoms and improves survival ...
Kuan‐Ting Chuang   +9 more
wiley   +1 more source

Incidence of symptomatic Covid‐19 infections in patients with mastocytosis and chronic myeloid leukemia: A comparison with the general Austrian population

open access: yesEuropean Journal of Haematology, Volume 110, Issue 1, Page 67-76, January 2023., 2023
Abstract Background The SARS‐COV‐2 (Covid‐19) pandemic has impacted the management of patients with hematologic disorders. In some entities, an increased risk for Covid‐19 infections was reported, whereas others including chronic myeloid leukemia (CML) had a lower mortality.
Irene Graf   +7 more
wiley   +1 more source

Treatment strategy for systemic lupus erythematosus using belimumab as indicated by multi‐omics analysis

open access: yesRheumatology &Autoimmunity, EarlyView.
Recent multi‐omics studies have demonstrated that belimumab specifically targets naïve B cells and a subset of memory B cells. This observation is consistent with belimumab's established efficacy and safety profile. Abstract Belimumab is an antibody targeting the cytokine B‐cell activating factor (BAFF), which is crucial for B cell differentiation, and
Keishi Fujio   +5 more
wiley   +1 more source

“Fight or flight”—A study of frontline emergency response workforce's perceived knowledge, and motivation to work during hazards “战斗或逃跑”——关于一线应急响应人员的感知知识和在危险期间的工作动机研究 “Lucha o huida”: Un estudio sobre el conocimiento percibido y la motivación para trabajar de la fuerza laboral de primera línea de respuesta a emergencias durante los peligros

open access: yesRisk, Hazards &Crisis in Public Policy, EarlyView.
Abstract This study aims to identify different frontline emergency response workforce's perceived knowledge of hazards and their willingness and motivations to go to work during them. An online version of the “Fight or Flight” survey was distributed and collected from Norwegian emergency personnel during the spring of 2023.
Jarle L. Sørensen   +9 more
wiley   +1 more source

Clinical characteristics, treatments, outcome, and prognostic factors of severe autoimmune encephalitis in the intensive care unit: Standard treatment and the value of additional plasma cell–depleting escalation therapies for treatment‐refractory patients

open access: yesEuropean Journal of Neurology, Volume 30, Issue 2, Page 474-489, February 2023., 2023
Our retrospective study analyzed 40 patients with intensive care unit (ICU)‐dependent autoimmune encephalitis (AE) for clinical characteristics, diagnostics, prognostic factors, and clinical outcomes regarding standard treatment in responsive patients versus additional escalation therapies for treatment‐refractory cases.
Lisa Schwarz   +4 more
wiley   +1 more source

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