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Improved adjuvanting of seasonal influenza vaccines: Pre-clinical studies of MVA-NP+M1 co-administration with inactivated influenza vaccine. [PDF]
Licensed seasonal influenza vaccines induce antibody responses against influenza hemagglutinin that are limited in their ability to protect against different strains of influenza.
Gilbert, SC +36 more
core +1 more source
The Next Generation of Influenza Vaccines: Towards a Universal Solution
Influenza viruses remain a constant burden in humans, causing millions of infections and hundreds of thousands of deaths each year. Current influenza virus vaccine modalities primarily induce antibodies directed towards the highly variable head domain of
Daniel Watterson +3 more
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Summary This report updates the 2020–21 recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the United States (MMWR Recomm Rep 2020;69[No. RR-8]).
L. Grohskopf +6 more
semanticscholar +1 more source
Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence [PDF]
Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals ...
Assir N +11 more
core +1 more source
Novel Influenza Vaccines: From Research and Development (R&D) Challenges to Regulatory Responses
Influenza vaccines faced significant challenges in achieving sufficient protective efficacy and production efficiency in the past. In recent decades, novel influenza vaccines, characterized by efficient and scalable production, advanced platforms, and ...
Yue Yang +3 more
core +1 more source
Evaluation of the preventive effectiveness of influenza vaccines in St. Petersburg
Background. The influenza vaccination coverage has steadily increased in the Russian Federation. The introduction of new domestic influenza vaccines into practice and the study of their effectiveness are of great importance for public health.
M. K. Erofeeva +8 more
doaj +1 more source
The poor immune response elicited by trivalent influenza vaccines (TIVs) in children can be enhanced by the addition of adjuvants. This observer-blind, randomized Phase III trial assessed the immunogenicity and safety of the MF59-adjuvanted trivalent ...
Aurelio Cruz-Valdez +7 more
doaj +1 more source
Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses
Dendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the polarization of T cell responses ...
Demo Yemane Tesfaye +8 more
doaj +1 more source
Aim. In this study we developed and characterized a mouse model of secondary S. aureus and S. pneumoniae pneumonia following influenza virus infection with H1N1 pandemic and laboratory strains and their reassortment. Materials and methods.
I. A. Leneva +7 more
doaj +1 more source
MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization. [PDF]
Human infections with highly pathogenic avian influenza viruses of the H5N1 subtype, frequently reported since 2003, result in high morbidity and mortality.
Sutter, G. (Gerd) +43 more
core +1 more source

