Results 231 to 240 of about 343,579 (311)

Streptococcus pneumoniae und Influenza A Virus induzierte Immunantwort in kultiviertem, humanem Lungengewebe und Zellkulturen

, 2014
Kolja Szymanski
openalex   +2 more sources

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Discovery of a novel broad-spectrum inhibitor against influenza virus A. [PDF]

Virol J
Yu R, Li P, Shen R, Fei W.
europepmc   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Loss of Dmrta1 alters CD8+ T cell activation and resistance to influenza virus infection. [PDF]

Immunohorizons
Kondo H, Otsuka K, Morimoto J, Arimochi H, Tsukumo SI, Yasutomo K.   +5 more
europepmc   +1 more source

High pathogenicity avian influenza (HPAI) H5N1 virus detected in brown Skua using portable laboratory while at sea in Antarctica

Michelle Thunders, Meagan Dewar, Yee Syuen Low, Andrew Wilson, Ruy Jáuregui, Anastasia Chernyavtseva, Joseph O’Keefe   +6 more
openalex   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Experimental infection of weanling pigs with A-swine influenza virus. 3. Immunity in piglets farrowed by antibody-bearing dams experimentally infected a year earlier.

, 1970
D Blaškovič, V. Rathová, D Kocisková, O Jamrichová, E Sádecký, Martin M. Kaplan   +5 more
openalex   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

ApoD mediates age-associated increase in vulnerability to influenza virus infection. [PDF]

Proc Natl Acad Sci U S A
Jiang Z, Pan W, Chen Y, Zhou D, Ren S, Tong Q, Liu L, Sun H, Sun Y, Bi Y, Wang D, Lu L, Pu J, Chang KC, Liu J.   +14 more
europepmc   +1 more source