Results 21 to 30 of about 343,579 (311)

Influenza Virus Nucleoprotein Interacts with Influenza Virus Polymerase Proteins [PDF]

Journal of Virology, 1998
ABSTRACT Influenza virus nucleoprotein (NP) is a critical factor in the viral infectious cycle in switching influenza virus RNA synthesis from transcription mode to replication mode. In this study, we investigated the interaction of NP with the viral polymerase protein complex.
S K, Biswas, P L, Boutz, D P, Nayak
openaire   +2 more sources

Middle East respiratory syndrome coronavirus infection in non-camelid domestic mammals

Emerging Microbes and Infections, 2019
Dromedary camels are natural host of the Middle East respiratory syndrome coronavirus (MERS-CoV). However, there are limited studies of MERS-CoV infection of other domestic mammals exposed to infected dromedaries.
Ahmed Kandeil, Mokhtar Gomaa, Mahmoud Shehata, Ahmed El-Taweel, Ahmed E. Kayed, Awatef Abiadh, Jamel Jrijer, Yassmin Moatasim, Omnia Kutkat, Ola Bagato, Sara Mahmoud, Ahmed Mostafa, Rabeh El-Shesheny, Ranawaka APM Perera, Ronald LW Ko, Nagla Hassan, Basma Elsokary, Lotfi Allal, Ahmed Saad, Heba Sobhy, Pamela P. McKenzie, Richard J. Webby, Malik Peiris, Mohamed A. Ali, Ghazi Kayali   +24 more
doaj   +1 more source

Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2

Molecules, 2021
Flavonoids are important secondary plant metabolites that have been studied for a long time for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory effects.
Ahmed A. Al-Karmalawy, Mai M. Farid, Ahmed Mostafa, Alia Y. Ragheb, Sara H. Mahmoud, Mahmoud Shehata, Noura M. Abo Shama, Mohamed GabAllah, Gomaa Mostafa-Hedeab, Mona M. Marzouk   +9 more
doaj   +1 more source

Baloxavir susceptibility of seasonal influenza viruses during the first seven seasons of clinical use in Japan, 2017/18 to 2023/24

Eurosurveillance
BACKGROUND: Baloxavir marboxil, a cap-dependent endonuclease inhibitor, was approved in Japan in February 2018 for treatment of influenza A and B infections, making Japan the first country to introduce its clinical use.
the Influenza Virus Surveillance Group of Japan
doaj   +1 more source

Diversity of Astroviruses Circulating in Humans, Bats, and Wild Birds in Egypt

Viruses, 2020
Astroviruses belong to Astroviridae family which includes two main genera: Mamastroviruses that infect mammals, and Avastroviruses that infect avian hosts. Bats and wild birds are considered among the natural reservoirs for astroviruses.
Ahmed El Taweel, Ahmed Kandeil, Ahmed Barakat, Omar Alfaroq Rabiee, Ghazi Kayali, Mohamed Ahmed Ali   +5 more
doaj   +1 more source

Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness

mBio, 2014
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses.
S. Schultz-Cherry, R. J. Webby, R. G. Webster, A. Kelso, I. G. Barr, J. W. McCauley, R. S. Daniels, D. Wang, Y. Shu, E. Nobusawa, S. Itamura, M. Tashiro, Y. Harada, S. Watanabe, T. Odagiri, Z. Ye, G. Grohmann, R. Harvey, O. Engelhardt, D. Smith, K. Hamilton, F. Claes, G. Dauphin   +22 more
doaj   +1 more source

Influenza Virus Entry [PDF]

, 2011
As all the enveloped viruses, the entry of influenza viruses includes a number of steps in host cell infection. This chapter summarizes the current knowledge of the entry pathway and the role of the fusion protein of influenza virus, hemagglutinin, in this process.
openaire   +2 more sources

Characterization and immunogenicity assessment of MERS-CoV pre-fusion spike trimeric oligomers as vaccine immunogen

Human Vaccines & Immunotherapeutics
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal beta-coronavirus that emerged in 2012. The virus is part of the WHO blueprint priority list with a concerning fatality rate of 35%.
Rahul Ahuja, Preeti Vishwakarma, Sneha Raj, Varun Kumar, Ritika Khatri, Bharat Lohiya, Shikha Saxena, Gurleen Kaur, Gagandeep Singh, Shailendra Asthana, Shubbir Ahmed, Sweety Samal   +11 more
doaj   +1 more source

Prokaryotic Expression of the Influenza A (H5N1) Neuraminidase

Journal of Mazandaran University of Medical Sciences, 2021
Background and purpose: Highly Pathogenic Influenza A(H5N1) viruses cause vast economic losses throughout the world. They may circulate in animals and be able to spread from human to human.
Zahra Latif, Behrokh Farahmand, Maryam Saleh, Zahra Barghi   +3 more
doaj  

Efficient protection of mice from influenza A/H1N1pdm09 virus challenge infection via high avidity serum antibodies induced by booster immunizations with inactivated whole virus vaccine

Heliyon, 2019
The immunogenicities of inactivated whole and split virus vaccines derived from influenza A/H1N1pdm09 virus were compared in a mouse model. We demonstrated the unique properties of whole virus vaccine boosters on the serum memory antibody response in ...
Kayoko Sato, Yoshimasa Takahashi, Yu Adachi, Hideki Asanuma, Manabu Ato, Masato Tashiro, Shigeyuki Itamura   +6 more
doaj   +1 more source