Results 41 to 50 of about 536,784 (299)

Characterization and immunogenicity assessment of MERS-CoV pre-fusion spike trimeric oligomers as vaccine immunogen

Human Vaccines & Immunotherapeutics
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal beta-coronavirus that emerged in 2012. The virus is part of the WHO blueprint priority list with a concerning fatality rate of 35%.
Rahul Ahuja, Preeti Vishwakarma, Sneha Raj, Varun Kumar, Ritika Khatri, Bharat Lohiya, Shikha Saxena, Gurleen Kaur, Gagandeep Singh, Shailendra Asthana, Shubbir Ahmed, Sweety Samal   +11 more
doaj   +1 more source

Prokaryotic Expression of the Influenza A (H5N1) Neuraminidase

Journal of Mazandaran University of Medical Sciences, 2021
Background and purpose: Highly Pathogenic Influenza A(H5N1) viruses cause vast economic losses throughout the world. They may circulate in animals and be able to spread from human to human.
Zahra Latif, Behrokh Farahmand, Maryam Saleh, Zahra Barghi   +3 more
doaj  

Efficient protection of mice from influenza A/H1N1pdm09 virus challenge infection via high avidity serum antibodies induced by booster immunizations with inactivated whole virus vaccine

Heliyon, 2019
The immunogenicities of inactivated whole and split virus vaccines derived from influenza A/H1N1pdm09 virus were compared in a mouse model. We demonstrated the unique properties of whole virus vaccine boosters on the serum memory antibody response in ...
Kayoko Sato, Yoshimasa Takahashi, Yu Adachi, Hideki Asanuma, Manabu Ato, Masato Tashiro, Shigeyuki Itamura   +6 more
doaj   +1 more source

Transmission dynamics of influenza in two major cities of Uganda

Epidemics, 2018
In this paper, we report the epidemic characteristics of the three co-circulating influenza viruses (i.e., A/H1N1, A/H3N2, and B) in two tropical African cities—Kampala and Entebbe, Uganda—over an eight-year period (2008–2015).
Wan Yang, Matthew J. Cummings, Barnabas Bakamutumaho, John Kayiwa, Nicholas Owor, Barbara Namagambo, Timothy Byaruhanga, Julius J. Lutwama, Max R. O’Donnell, Jeffrey Shaman   +9 more
doaj   +1 more source

Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017

Viruses, 2019
The surveillance and virological characterization of H5N8 avian influenza viruses are important in order to assess their zoonotic potential. The genetic analyses of the Egyptian H5N8 viruses isolated through active surveillance in wild birds and domestic
Yassmin Moatasim, Ahmed Kandeil, Basma Emad Aboulhoda, Rabeh El-Shesheny, Maha Alkhazindar, Elsayed Tarek AbdElSalam, Omnia Kutkat, Mina Nabil Kamel, Ahmed Nageh El Taweel, Ahmed Mostafa, Joseph T. Hicks, Sary Khaleel Abd elghaffar, Ghazi Kayali, Mohamed Ahmed Ali   +13 more
doaj   +1 more source

Sinapic Acid Suppresses SARS CoV-2 Replication by Targeting Its Envelope Protein

Antibiotics, 2021
SARS CoV-2 is still considered a global health issue, and its threat keeps growing with the emergence of newly evolved strains. Despite the success in developing some vaccines as a protective measure, finding cost-effective treatments is urgent ...
Raha Orfali, Mostafa E. Rateb, Hossam M. Hassan, Mona Alonazi, Mokhtar R. Gomaa, Noura Mahrous, Mohamed GabAllah, Ahmed Kandeil, Shagufta Perveen, Usama Ramadan Abdelmohsen, Ahmed M. Sayed   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ducks induce rapid and robust antibody responses than chickens at early time after intravenous infection with H9N2 avian influenza virus

Virology Journal, 2019
Background Compared with chickens, ducks are normally resistant to avian influenza virus without clinical signs while they habor almost all subtypes of influenza A viruses.
Jianmei Yang, Hongrui Cui, Qiaoyang Teng, Wenjun Ma, Xuesong Li, Binbin Wang, Dawei Yan, Hongjun Chen, Qinfang Liu, Zejun Li   +9 more
doaj   +1 more source

Viral respiratory infections in very low birthweight infants at neonatal intensive care unit: prospective observational study

BMJ Paediatrics Open, 2020
Background and objective Very low birthweight (VLBW) infants are highly susceptible to respiratory infections. Information about prevalence of viral respiratory infections (VRIs) in neonatal intensive care unit (NICU) is scarce.
Cristina Calvo, Inmaculada Casas, Laura Sánchez García, Francisco Pozo, Adelina Pellicer   +4 more
doaj   +1 more source

Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics

Antibiotics, 2021
Since the emergence of the SARS-CoV-2 pandemic in 2019, it has remained a significant global threat, especially with the newly evolved variants. Despite the presence of different COVID-19 vaccines, the discovery of proper antiviral therapeutics is an ...
Hani A. Alhadrami, Ahmed M. Sayed, Hossam M. Hassan, Khayrya A. Youssif, Yasser Gaber, Yassmin Moatasim, Omnia Kutkat, Ahmed Mostafa, Mohamed Ahmed Ali, Mostafa E. Rateb, Usama Ramadan Abdelmohsen, Noha M. Gamaleldin   +11 more
doaj   +1 more source