Results 51 to 60 of about 536,784 (299)

Influenza Vaccination of young children or Antibody Immune Response and Protection after Inactivated Influenza Vaccine in Children – A Literature Review [PDF]

, 2020
Influenza virus infection is a major cause of morbidity and mortality in at risk populations. Children, especially under the age of two, are at an increased risk of complications associated with influenza virus infection.
wall, danielle
core   +1 more source

Canalization of the evolutionary trajectory of the human influenza virus [PDF]

, 2011
Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like ...
A Kucharski, A Monto, A Park, A Rambaut, Andrew Rambaut, B Adams, B Finkelman, C Viboud, CA Russell, D Weinreich, DJ Smith, E Goldstein, E O'Dea, E Volz, F Carrat, F Tria, G Chowell, G Hirst, IG Barr, J Gog, J Lin, J O'Brien, J Truscott, J Voeten, K Koelle, K Koelle, K Koelle, K Koelle, M Recker, Mercedes Pascual, MI Nelson, NM Ferguson, R Bush, S Bhatt, S Gould, S Kryazhimskiy, S Park, T Bedford, T Bedford, Trevor Bedford, V Gupta, WM Fitch, YI Wolf, Z Yang   +43 more
core   +5 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Respiratory microbes detected in hospitalized adults with acute respiratory infections: associations between influenza A(H1N1)pdm09 virus and intensive care unit admission or fatal outcome in Vietnam (2015–2017)

BMC Infectious Diseases, 2021
Background Acute respiratory tract infection (ARI) is a leading cause of hospitalization, morbidity, and mortality worldwide. Respiratory microbes that were simultaneously detected in the respiratory tracts of hospitalized adult ARI patients were ...
Phuong Thai Truong, Shinji Saito, Ikuyo Takayama, Hiroyuki Furuya, Binh Gia Nguyen, Thanh Van Do, Phuong Thu Phan, Cuong Duy Do, Co Xuan Dao, Thach The Pham, Tuan Quoc Dang, Chau Quy Ngo, Ngan Thi Le, Vuong Minh Bui, Dung Trung Le, Van Thi Tuong Vu, Thuy Thi Phuong Pham, Takeshi Arashiro, Tsutomu Kageyama, Noriko Nakajima   +19 more
doaj   +1 more source

Evolutionary Dynamics of H5 Highly Pathogenic Avian Influenza Viruses (Clade 2.3.4.4B) Circulating in Bulgaria in 2019–2021

Viruses, 2021
The first detection of a Highly Pathogenic Avian Influenza (HPAI) H5N8 virus in Bulgaria dates back to December 2016. Since then, many outbreaks caused by HPAI H5 viruses from clade 2.3.4.4B have been reported in both domestic and wild birds in different
Bianca Zecchin, Gabriela Goujgoulova, Isabella Monne, Annalisa Salviato, Alessia Schivo, Iskra Slavcheva, Ambra Pastori, Ian H. Brown, Nicola S. Lewis, Calogero Terregino, Alice Fusaro   +10 more
doaj   +1 more source

The use of equine influenza pseudotypes for serological screening [PDF]

, 2012
Standard assays used for influenza serology present certain practical issues, such as inter-laboratory variability, complex protocols and the necessity for handling certain virus strains in high biological containment facilities.
Böttcher-Friebertshäuser, Eva, Daly, Janet, Ferrara, Francesca, Molesti, Eleonora, Scott, Simon, Temperton, Nigel   +5 more
core   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Aged AG129 mice support the generation of highly virulent novel mouse-adapted DENV (1-4) viruses exhibiting neuropathogenesis and high lethality

Virus Research
Dengue virus infection in humans ranges from asymptomatic infection to severe infection, with ∼2.5 % overall disease fatality rate. Evidence of neurological manifestations is seen in the severe form of the disease, which might be due to the direct ...
Gazala Siddqui, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Sneh Bajpai, Amit Kumar, Satish Kumar, Ritika Khatri, Jaskaran Kaur, Sankar Bhattacharya, Shubbir Ahmed, Gulam Hussain Syed, Yashwant Kumar, Sweety Samal   +13 more
doaj   +1 more source

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

Nature Communications, 2022
The SARS-CoV-2 variant of concern Omicron, has been reported to mainly use the endocytosis pathway for viral entry, bypassing the furin/TMPRSS2 pathway utilised by other variants. Here, the authors test a panel of SARS-CoV-2 variants in TMPRSS2 knock out
Naoko Iwata-Yoshikawa, Masatoshi Kakizaki, Nozomi Shiwa-Sudo, Takashi Okura, Maino Tahara, Shuetsu Fukushi, Ken Maeda, Miyuki Kawase, Hideki Asanuma, Yuriko Tomita, Ikuyo Takayama, Shutoku Matsuyama, Kazuya Shirato, Tadaki Suzuki, Noriyo Nagata, Makoto Takeda   +15 more
doaj   +1 more source