Results 61 to 70 of about 536,784 (299)

First detection of SARS-CoV-2 variant B.1.1.529 (Omicron) in Ecuador

New Microbes and New Infections, 2022
The National Institute of Research and Public Health reported the first local record of the Omicron variant detected in Ecuador. A fully vaccinated subject returned from South Africa with a negative RT-PCR.
A. Carrazco-Montalvo, I. Armendáriz-Castillo, C.L. Tello, D. Morales, R. Armas-Gonzalez, D. Guizado-Herrera, A. León-Sosa, D. Ramos-Sarmiento, B. Fuertes, L. Patino, P. Cárdenas, S. Márquez, B. Prado-Vivar, J.J. Guadalupe, B. Gutiérrez, M.B. Wong, M. Grunauer, G. Trueba, P. Rojas-Silva, V. Barragán   +19 more
doaj   +1 more source

Viruses disrupt functions of human lymphocytes. Effects of measles virus and influenza virus on lymphocyte-mediated killing and antibody production. [PDF]

, 1984
We present experimental data that offer, in part, a better understanding of the immunosuppression that accompanies measles virus infection. We note that measles virus "silently" infects human lymphocytes and that the infection does not alter lymphocyte ...
Casali, P, Oldstone, MB, Rice, GP
core  

Integrating influenza antigenic dynamics with molecular evolution. [PDF]

, 2013
Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains ...
Abed, Ansaldi, Ansaldi, Barr, Barr, Bedford, Bedford, Bogner, Borodin, Cai, Centers for Disease Control and Prevention, Chakraverty, Chakraverty, Cox, Cox, Daniels, Daum, Daum, Donatelli, Drummond, Edgar, Ferguson, Fitch, Gog, Goldstein, Gust, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hay, Hensley, Hirst, Kanegae, Kendal, Klimov, Koel, Lemey, Li, Lin, Lin, Lin, Lin, Matsuzaki, McCauley, McCauley, McCauley, McCauley, McCauley, McDonald, Muyanga, Nakagawa, Nakajima, Nakajima, Nakajima, Nelson, Nerome, Oh, Osterholm, Pagel, Pereira, Puzelli, Pybus, Raymond, Rota, Russell, Shapiro, Shaw, Smith, Squires, Stevens, Webster, Wiley, World Health Organization, Xu   +83 more
core   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

Nature Communications
The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription or replication of the ...
Tim Krischuns, Benoît Arragain, Catherine Isel, Sylvain Paisant, Matthias Budt, Thorsten Wolff, Stephen Cusack, Nadia Naffakh   +7 more
doaj   +1 more source

Detection of Influenza and Other Respiratory Pathogens by RT-qPCR and Characterization by Genomic Sequencing Using ILI/SARI Hospital-Based Sentinel Surveillance System

Viruses
Limited surveillance and laboratory testing for non-influenza viruses remains a challenge in Uganda. The World Health Organization (WHO) designated National Influenza Center (NIC) tested samples from patients with influenza-like illness (ILI) and severe ...
Charity A. Nassuna, Fahim Yiga, Joweria Nakaseegu, Esther Amwine, Bridget Nakamoga, Noel Ayuro, Nicholas Owor, David Odongo, Jocelyn Kiconco, Thomas Nsibambi, Samuel Wasike, Ben Andagalu, Chelsea Harrington, Adam W. Crawley, Julius Ssempiira, Ray Ransom, Amy L. Boore, Barnabas Bakamutumaho, John T. Kayiwa, Julius J. Lutwama   +19 more
doaj   +1 more source

Propagation of Rhinovirus C in Differentiated Immortalized Human Airway HBEC3-KT Epithelial Cells

Viruses, 2019
Rhinoviruses (RVs) are classified into three species: RV-A, B, and C. Unlike RV-A and -B, RV-C cannot be propagated using standard cell culture systems. In order to isolate RV-Cs from clinical specimens and gain a better understanding of their biological
Mina Nakauchi, Noriyo Nagata, Ikuyo Takayama, Shinji Saito, Hideyuki Kubo, Atsushi Kaida, Kunihiro Oba, Takato Odagiri, Tsutomu Kageyama   +8 more
doaj   +1 more source

Further evidence of the circulation of PMV-4 and influenza viruses with N2 - 1957 enzyme in migratory waterfowls [PDF]

, 1989
I n the years 1980—1984, one paramyxovirus type 4 and 11 influenza viruses were isolated from cloacal swabs collected from migratory waterfowls in Fed. Rep. Germany.
Bachmann, P. A., Eichhorn, Werner, Pfleger, A., Stumpa, A., Tumova, B.   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Newcastle disease virus in Egyptian domestic poultry, 2019–2021: Molecular characterization, phylogenetic analysis, and coinfection with avian influenza A virus

Open Veterinary Journal
Background: Newcastle Disease Virus (NDV) is a major viral disease of poultry that causes outbreaks in chickens in Egypt. Aim: The aim of this study was to determine the prevalence and molecular characteristics of NDV and its cocirculation with avian
Ahmed El Taweel, Mohamed El Sayes, Asmaa Maatouq, Mokhtar Gomaa, Yassmin Moatasim, Omnia Kutkat, Pamela P. McKenzie, Ahmed Kandeil, Richard J. Webby, Mohamed Ahmed Ali, Ghazi Kayali, Rabeh El-Shesheny   +11 more
doaj   +1 more source