Results 61 to 70 of about 2,123,414 (312)

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

eLife, 2020
Seasonal influenza virus A/H3N2 is a major cause of death globally. Vaccination remains the most effective preventative. Rapid mutation of hemagglutinin allows viruses to escape adaptive immunity. This antigenic drift necessitates regular vaccine updates.
John Huddleston, John R Barnes, Thomas Rowe, Xiyan Xu, Rebecca Kondor, David E Wentworth, Lynne Whittaker, Burcu Ermetal, Rodney Stuart Daniels, John W McCauley, Seiichiro Fujisaki, Kazuya Nakamura, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Ian Barr, Kanta Subbarao, Pierre Barrat-Charlaix, Richard A Neher, Trevor Bedford   +19 more
doaj   +1 more source

Impact of Protein Nitration on Influenza Virus Infectivity and Immunogenicity

Microbiology Spectrum, 2022
Influenza viruses are deadly respiratory pathogens of special importance due to their long history of global pandemics. During influenza virus infections, the host responds by producing interferons, which activate interferon-stimulated genes (ISGs ...
Harrison Dulin, Nathan Hendricks, Duo Xu, Linfeng Gao, Keidy Wuang, Huiwang Ai, Rong Hai   +6 more
doaj   +1 more source

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Nature Communications, 2018
Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus
N. Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, B. Mui, Ying K. Tam, K. Karikó, Chris Barbosa, T. D. Madden, M. Hope, F. Krammer, S. Hensley, D. Weissman   +13 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Neurogenic pulmonary edema following febrile status epilepticus in a 22-month-old infant with multiple respiratory virus co-detection: a case report

BMC Infectious Diseases, 2020
Background Neurogenic pulmonary edema is a rare but serious complication of febrile status epilepticus in children. Comprehensive screening for viral pathogens is seldomly performed in the work-up of febrile children.
Yoshie Takagi, Takeaki Imamura, Shota Endo, Kenta Hayashi, Satoka Akiyama, Yoji Ikuta, Takahiro Kawaguchi, Tomoko Sumita, Tatsuo Katori, Masanori Hashino, Shinji Saito, Takato Odagiri, Kunihiro Oba, Makoto Kuroda, Tsutomu Kageyama   +14 more
doaj   +1 more source

Disease burden caused by respiratory syncytial virus compared with influenza among adults: a retrospective cohort study from Eastern Finland in 2017–2018 [PDF]

, 2022
Aleksi Hämäläinen, Ellamaria Savinainen, Sari Hämäläinen, Katariina Sivenius, Juha Kauppinen, Irma Koivula, Riitta-Liisa Patovirta   +6 more
openalex   +1 more source

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

Scientific Reports, 2018
Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses.
S. Omoto, V. Speranzini, Takashi Hashimoto, Takeshi Noshi, H. Yamaguchi, M. Kawai, K. Kawaguchi, T. Uehara, T. Shishido, A. Naito, S. Cusack   +10 more
semanticscholar   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration

Human Vaccines & Immunotherapeutics, 2018
Unlike the current injectable influenza vaccines, intranasally administered influenza vaccines induce influenza virus-specific IgA antibodies in the local respiratory mucosa as well as IgG antibodies in the systemic circulation. Our previous study showed
Yoshihiko Terauchi, Kaori Sano, Akira Ainai, Shinji Saito, Yuki Taga, Kiyoko Ogawa-Goto, Shin-ichi Tamura, Takato Odagiri, Masato Tashiro, Mikiya Fujieda, Tadaki Suzuki, Hideki Hasegawa   +11 more
doaj   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source