Results 51 to 60 of about 6,301,927 (304)

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego   +10 more
wiley   +1 more source

A software development framework for hardware centric applications: an architectural perspective [PDF]

open access: yes, 2008
Throughout the history of Software Engineering, software development has been looked at from various perspectives, in terms of: usability, suitability for proposed problem, speed of development, relevance to real world scenarios, as well as in terms of ...
1st Workshop in Information and Communication Technology (WICT 2008)   +2 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Joint Decoupling Optimization of Frequency Offsets and Array Elements for Frequency Diverse Arrays

open access: yesInternational Journal of Antennas and Propagation
Frequency diverse array (FDA) has a distance-angle–dependent beam direction map, which has a greater application advantage than phased array. However, due to the distance-angle coupling and periodicity of its beam direction map, it makes the parameter ...
Yuming Lu   +4 more
doaj   +1 more source

A Varactor-Tunable Rasorber Using Tripole and Ring Slot Elements

open access: yesInternational Journal of Antennas and Propagation, 2021
In this study, a frequency-selective rasorber with a tunable passband and two absorptive bands is presented. It is designed using two active FSSs, an absorptive FSS realized with tripole elements, and a lossless bandpass FSS achieved with ring slots ...
Qingxin Guo   +3 more
doaj   +1 more source

Offline handwritten signature verification using radial basis function neural network [PDF]

open access: yes, 2007
This study investigates the effectiveness of Radial Basis Function Neural Networks (RBFNNs) for Of- fline Handwritten Signature Verification (OHSV). A signature database is collected using intrapersonal variations for evaluation. Global, grid and texture
Azzopardi, George   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Information driven SDLC concepts [PDF]

open access: yes, 2008
Although software engineering has matured greatly over the years, a large number of ICT projects continue to fail. Studies continue to identify non-technical issues such as poor communication, shifting requirements and poor executive involvement as the ...
1st Workshop in Information and Communication Technology (WICT 2008)   +2 more
core  

What are the affordances of information and communication technologies? [PDF]

open access: yes, 2004
The paper examines the notion that Information and Communication Technologies (ICT) have affordances that epitomize the features of our late modern age (Giddens, 1991) and explores whether these affordances (Salomon, 1993, p.
Conole, Grainne, Dyke, Martin
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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