Results 61 to 70 of about 6,301,927 (304)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Conflict analysis of deontic contracts [PDF]

open access: yes, 2008
Industry is currently pushing towards Service Oriented Architecture where code execution is not limited to the organisational borders but may extend outside of the organisation to which the sources are typically not accessible.
Fenech, Stephen   +3 more
core  

Fashion and Communication Training for A Quality Information [PDF]

open access: yes, 2016
Our research group Media Studio for quality journalism by the excellence project “Quality Journalism to new digital journalistic formats” has rescued a tool to measure the quality of the contents and to analyze treatment of specialized contents.
Luque Ortiz, Sergio   +1 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

An architecture supporting compensation-aware monitoring [PDF]

open access: yes, 2010
To avoid large overheads induced by runtime monitoring, the use of asynchronous log-based monitoring is sometimes adopted — even though this implies that the system may proceed further despite having reached an anomalous state.
Abela, Patrick   +3 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

THЕ RЕLATIONSHIP BЕTWЕЕN CORPORATЕ GOVЕRNANCЕ AND RISK MANAGЕMЕNT [PDF]

open access: yesAnnals of the University of Craiova: Economic Sciences Series, 2019
Corporatе Govеrnancе is thе branch of thе еconomy that studiеs how companiеs can bеcomе morе еfficiеnt by using institutional structurеs as constitutivе acts, organizational charts and lеgislativе framеwork.
Ionuț Riza   +2 more
doaj  

A domain-specific embedded language approach for the scripting of game artificial intelligence [PDF]

open access: yes, 2009
A computer game’s artificial intelligence is often scripted using a domain-specific language designed specifically for the game. An approach to language design and prototyping, particularly appropriate to domain-specific ones, is that of embedding a ...
2nd WICT National Workshop in Information and Communication Technology (WICT 2009)   +2 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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