Results 81 to 90 of about 1,288,742 (268)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Preface

open access: yesInformation Processing in Agriculture, 2014
Daoliang Li, Prof. Director of China-EU Center for Information & Communication Technologies in Agriculture (CICTA), China Agricultural University and Chair of WG5.14, IFIP TC5
doaj   +1 more source

Information and Communication Technologies Use for the Competitiveness of Business Organizations

open access: yesÈkonomika, Pedagogika i Pravo, 2016
In this article author examines some of the issues of information and communication technologies in order to ensure the competitiveness of enterprise structures in the field of education and science of the Russian Federation at the present stage.
Alexander A. Galushkin
doaj  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Where Is the Information in Animal Communication?

open access: yes, 2011
Communication is a central topic in animal behavior studies and yet the dispute over what constitutes communication is far from settled. This chapter provides an integrative framework that views communication, in its elementary form, as an interaction between two individuals (sender and receiver) involving the use of signals by the sender as well as ...
Fischer, Julia   +2 more
openaire   +3 more sources

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang   +4 more
wiley   +1 more source

Entity-relation pair attention-based representation with knowledge graph for media-content cross-domain recommendation

open access: yesComplex & Intelligent Systems
With the popularity of Internet services and the explosive growth of information, recommendation algorithm have become increasingly crucial in the all-media era.
Tongtong Xing   +4 more
doaj   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie   +8 more
wiley   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song   +10 more
wiley   +1 more source

Information in the HIV+ community [PDF]

open access: yesProceedings of the American Society for Information Science and Technology, 2003
Timothy P. Hogan, Carole L. Palmer
openaire   +1 more source

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