Results 71 to 80 of about 4,442 (241)
Design and Evaluation of Probabilistic Caching in Information-Centric Networking
IEEE Access, 2018 In-network caching is a key feature of information-centric networking (ICN). However, challenges still exist in ICN caching such as how to place content replicas among cache nodes to maximize cache system benefits without introducing too much overhead ...
Haibo Wu +4 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
An Efficient Distributed Content Store-Based Caching Policy for Information-Centric Networking. [PDF]
Sensors (Basel), 2022 Dinh NT, Kim Y.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Information-Centric Networking in Wireless Environments: Security Risks and Challenges. [PDF]
IEEE Wirel Commun, 2021 Nour B +3 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
A Software-Defined Information-Centric Network Architecture
Guangtongxin yanjiu, 2016 Existing proposals of Software-Defined Information-Centric Networking（SDICN）are difficult to support massive content delivery and to enable respective updates of switching and buffering components.This motivates us to propose an overlay-based SDICN ...
LI Keng, CHEN Jing-wen, JIANG Yu, MA Lin
doaj
IVCN: Information-Centric Network Slicing Optimization Based on NFV in Fog-Enabled RAN
IEEE Access, 2019 Content service has become the most popular service that occupies plenty of caching and networking resources. In order to deliver content to end users with high QoE and low infrastructure cost, network function virtualization is deemed as a promising ...
Hao Jin, Haiya Lu, Yi Jin, Chenglin Zhao
doaj +1 more source