Results 61 to 70 of about 1,465,916 (268)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Pain: A Culturally Informed Experience [PDF]
Pain Research and Management, 2002 I was raised in North America ‐ a culture and society in which the education emphasizes knowledge about science, its methods and its principles. The scientific method of understanding, coupled with the rudimentary knowledge that I was taught in high school biology, resulted in my conceptualization of pain as an objective truth.
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Liens faibles, méfiance et apprentissage collectif
Je-LKS: Journal of E-Learning and Knowledge Society, 2009 The paper focuses on the relevance of the social structures involved in the development of a collaborative learning process. It analyses the issue concerning the relationship between the necessary trust in the didactic contract, the devolution to ...
Eric Delamotte
doaj +1 more source
Enablers of Information Security Culture
Procedia Economics and Finance, 2015 AbstractThe aim of our article is to provide arguments for a poly-contextual and dynamic approach to information security risk culture. We consider the correlation of memes as DNA (DeoxyriboNucleic Acid) of the mind with knowledge and the organizational context. Our approach is interpretivist, reflective and dialectic (Cecez-Kecmanovic, 2011). It seeks
Munteanu, Adrian-Bogdanel +1 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
RECIIS, 2009 To complete communication between researchers studies and science popularization studies a new way in scientific communication is open by the author, the one between professionals and researchers.
Viviane Couzinet
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
DEVELOPMENT OF INFORMATION CULTURE OF STUDENTS OF HUMANITARIAN SPECIALITIES
Інформаційні технології і засоби навчання, 2019 Issues related to information culture evoke a natural interest of Ukrainian and foreign researchers. In addition to purely technical aspects and the development of competency characteristics, the problem of the development of students’ information ...
Анатолій Володимирович Вихрущ +5 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source