Results 81 to 90 of about 1,465,916 (268)

МЕТОДЫ ПОВЫШЕНИЯ ИНФОРМАЦИОННОЙ КУЛЬТУРЫ ПРИ РАЗВИТИИ ИССЛЕДОВАТЕЛЬСКИХ И ТВОРЧЕСКИХ СПОСОБНОСТЕЙ ОБУЧАЕМЫХ НА ОСНОВЕ КРЕАТИВНОГО МЫШЛЕНИЯ

Sovremennye Issledovaniâ Socialʹnyh Problem, 2013
В статье рассматриваются методы повышения информационной культуры при развитии исследовательских и творческих способностей обучаемых на основе креативного мышления.Цель: рассмотреть методы повышения информационной культуры при развитии исследовательских ...
Наила Алигасановна Теплая
doaj  

A Man of the Future and the Modern Education Policy [PDF]

Future Human Image, 2017
The problem of cultural elite forming out of high-educated men is discussed in the article. The basic education directives for problem decision are: self-education in and out of education process, the integral (natural-scientific and humanitarian ...
Vladimir Gukhman
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

ANALYSIS DEFINITIONS OF BASIC RESEARCH INFORMATION CULTURE OF FUTURE navigators

Ìнформаційні технології в освіті, 2016
Based on analysis of data sources, professionally-oriented products with cultural and activity approaches clarified the definition of basic research - "information activities", "information behavior", "information need", "world news".
Mikhailo Sherman, Oleg Bezbah
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Fake News Observatory: a teaching resource to cultivate an informed civic culture in Brazil

Revue Internationale d’Éducation de Sèvres
Inspired by Paulo Freire’s Pedagogy of Freedom, this text advocates an educational paradigm that fosters critical awareness, curiosity, and ethical discernment in the context of online information.
Lorena Tavares de Paula
doaj   +1 more source

Business Information Culture

Information Research: An International Electronic Journal, 2000
This research project is going to review the existing information cultures in 15 Finnish insurance businesses through a qualitative study. The interview-material consists of 40 in-depth-interviews and they are being analysed through the multiple case study method. The analysis is conducted in 5 stages considering information environment, information as
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source