Results 51 to 60 of about 556,681 (266)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Diffusion of multiple information: On information resilience and the power of segregation [PDF]
Games and Economic Behavior, 2015 We introduce two pieces of information, denoted memes, into a diffusion process in which memes are transmitted when individuals meet and forgotten at an exogenous rate. At most one meme can be transmitted at a meeting, which introduces opportunity costs in the process.
Tabasso, Nicole, Tabasso, Nicole
openaire +7 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
International Journal of Digital Earth, 2018 Many scholars have argued that the importance of geographic proximity in human interactions has been diminished by the use of the Internet, while others disagree with this argument. Studies have noted the distance decay effect in both cyberspace and real
Su Yeon Han +2 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
An Extended Firefly Algorithm for Enhanced Information Diffusion with Multi-Factor Considerations
Syrian Journal for Science and InnovationUnderstanding and predicting how information spreads in online social networks is a crucial yet complex task, especially with the growing influence of content type, user engagement, and social dynamics.
Amjad Alloush +2 more
doaj +1 more source
A Survey on Information Diffusion in Online Social Networks: Models and Methods
Information, 2017 By now, personal life has been invaded by online social networks (OSNs) everywhere. They intend to move more and more offline lives to online social networks. Therefore, online social networks can reflect the structure of offline human society.
Mei Li +3 more
doaj +1 more source
Information-Theoretic Discrete Diffusion
CoRRAccepted at NeurIPS ...
Moongyu Jeon +3 more
openaire +2 more sources