Results 61 to 70 of about 17,125,973 (292)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Diffusion of Information in Medical Care [PDF]
Journal of Economic Perspectives, 1992 This paper presents evidence that doctors behave very differently in making treatment recommendations depending on the region where they work, creating large variations in the quantities of care delivered to seemingly standardized populations. This evidence on “variations” (and the failure of normal explanations of the variations) leaves almost by ...
openaire +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Diffusion of multiple information: On information resilience and the power of segregation [PDF]
Games and Economic Behavior, 2015 We introduce two pieces of information, denoted memes, into a diffusion process in which memes are transmitted when individuals meet and forgotten at an exogenous rate. At most one meme can be transmitted at a meeting, which introduces opportunity costs in the process.
Tabasso, Nicole, Tabasso, Nicole
openaire +8 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
An information diffusion Fano inequality
CoRR, 2015 In this note, we present an information diffusion inequality derived from an elementary argument, which gives rise to a very general Fano-type inequality. The latter unifies and generalizes the distance-based Fano inequality and the continuous Fano inequality established in [Corollary 1, Propositions 1 and 2, arXiv:1311.2669v2], as well as the ...
Gábor Braun, Sebastian Pokutta
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Cube-based diffusion algorithm [PDF]
, 2007 We study molecular diffusion in (linear) nanopores with different types of roughness in the so-called Knudsen regime. Knudsen diffusion represents the limiting case of molecular diffusion in pores, where mutual encounters of the molecules within the free
Kärger, Jörg +3 more
core +1 more source
An Extended Firefly Algorithm for Enhanced Information Diffusion with Multi-Factor Considerations
Syrian Journal for Science and InnovationUnderstanding and predicting how information spreads in online social networks is a crucial yet complex task, especially with the growing influence of content type, user engagement, and social dynamics.
Amjad Alloush +2 more
doaj +1 more source