Results 101 to 110 of about 27,176,024 (344)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

WHO’s support for COVID-19 research and knowledge management in the Eastern Mediterranean Region

BMJ Global Health, 2022
Arash Rashidian, Lubna Al Ariqi, Sumithra Krishnamurthy Reddiar, Kaiyue Wu, Eman Aly, Ahmed Mandil, Amal Barakat, Chiori Kodama, Mehrnaz Kheirandish, Hatem Nour Eldin Hassan, Henry Victor Doctor, Nilmini Hemachandra, Kamal Fahmy, Phillip Dingwall, Mohamed Nour   +14 more
doaj   +1 more source

Information dissemination in mobile networks

, 2023
This thesis proposes some solutions to relieve, using Wi-Fi wireless networks, the data consumption of cellular networks using cooperation between nodes, studies how to make a good deployment of access points to optimize the dissemination of contents, analyzes some mechanisms to reduce the nodes' power consumption during data dissemination in ...
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Research on Agricultural Scientific and Technological Information Dissemination System Based on Complex Network Technology

, 2017
International audienceIn view of the complexity of information dissemination in agriculture and the uncertainty of farmers’ demand for scientific and technological information, this paper makes a comprehensive and accurate analysis for the dissemination ...
Chen, Hang, Zhang, Ying, Chen, Guifen, Gu, HongJun   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Determining smallholder farmers’ preferences for Push-Pull technology dissemination pathways in western Kenya [PDF]

The push-pull technology (PPT) has widely been disseminated to control stemborer (Chilo partellus and Busseola fusca) and Striga weeds (Striga hermonthica and Striga asiatica) in maize fields in Kenya. This study examined farmers’ preferences for various
Khan, Zeyaur R., Obare, Gideon A., Murage, Alice W., Amudavi, David M., Chianu, Jonas   +4 more
core  

Crisis Response Information Networks [PDF]

, 2012
Journal of the Association of Information Systems13131 ...
Leidner, Dorothy E., Pan, G., Leidner, D.E., PAN, Shan L., PAN, Gary, Pan, S.L., LEIDNER, Dorothy, Shan Pan, null null, Dorothy Leidner, Gary Pan   +10 more
core   +1 more source

Sciences / Management of Information Retrieval and Dissemination [PDF]

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2010
In this paper, the author presents the significance of denomination as well as the point that, name must contain the main functions of the scientific field and be of consensus.
Gholamreza Fadaie
doaj