Results 121 to 130 of about 3,171,091 (298)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Evaluation of the Information Systems Research Framework : Empirical Evidence from a Design Science Research Project

, 2016
The purpose of this paper is to provide empirical evidence that the design science framework Information System Research (ISR) works in practice.
Göbel, Hannes,, Cronholm, Stefan,
core  

A proposal for the evaluation of adaptive information retrieval systems using simulated interaction [PDF]

, 2010
The Centre for Next Generation Localisation (CNGL) is involved in building interactive adaptive systems which combine Information Retrieval (IR), Adaptive Hypermedia (AH) and adaptive web techniques and technologies.
Lawless, Séamus, Mulwa, Catherine, Li, Wei B., Jones, Gareth J.F.   +3 more
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Improving Estimates of Land–Atmosphere Coupling Through a Novel Framework of Land Aridity Classification

Geophysical Research Letters
The evapotranspiration (ET) regime is an illustration of the water‐energy interactions at the land surface and is important for regional climate. In this study, we propose a revised framework for land aridity classification based on the ET regime and the
Yufeng Shan, Jiangfeng Wei, Beilei Zan
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Six Generic Types of Information Systems Evaluation

, 2003
 The aim of this paper is to contribute to the decision of how to perform evaluation depending on the evaluation context. Three general strategies of how to perform evaluation together with two general strategies of what to evaluate are identified.
Cronholm, Stefan,, Goldkuhl, Göran,
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Four Decades of Scientific Activity in Iran from the Perspective of the Conference Proceedings, Highly Cited and Hot Papers, and Open Access Papers, in the Light of the Law of Economic, Social, and Cultural Development Plan of Iran

Iranian Journal of Information Processing & Management, 2018
This study aims to investigate Iran scientific production pre-revolutionary by 2016 with the emphasis on the conferences proceedings, highly cited and hot papers, and open access papers, in the light of the Law of Economic, Social, and Cultural ...
Mohammad Reza Ghane, Samira Kumarsi
doaj  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source