Results 71 to 80 of about 802,587 (260)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Separation and Recovery of Geophysical Signals Based on the Kalman Filter with GRACE Gravity Data

open access: yesRemote Sensing, 2019
Monthly gravitational field solutions as spherical harmonic coefficients produced by the GRACE satellite mission require post-processing to reduce the effects of shortwave-length noises and north⁻south stripe errors.
Xiaolong Wang   +6 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Preventing DDoS using Bloom Filter: A Survey

open access: yesEAI Endorsed Transactions on Scalable Information Systems, 2018
Distributed Denial-of-Service (DDoS) is a menace for service provider and prominent issue in network security. Defeating or defending the DDoS is a prime challenge. DDoS make a service unavailable for a certain time.
Ripon Patgiri   +2 more
doaj   +1 more source

Informativeness of Parallel Kalman Filters [PDF]

open access: yesMathematical and Computational Applications, 2004
This article considers the informativeness of parallel Kalman filters. Expressions are derived for determination of the amount of information obtained by additional measurements with a reserved measurement channel during processing. The theorems asserting that there is an increase in the informativeness of Kalman filters when there is a failure-free ...
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Modeling and Simulation of English Speech Rationality Optimization Recognition Based on Improved Particle Filter Algorithm

open access: yesComplexity, 2020
As one of the most important communication tools for human beings, English pronunciation not only conveys literal information but also conveys emotion through the change of tone.
Hui Dong
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

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