Results 71 to 80 of about 16,796,516 (235)
Filter Synthesis Using Genesys S/Filter
, 2016 S/Filter includes tools beyond direct synthesis, including a wide variety of both exact and approximate equivalent network transforms, methods for selecting the most desirable out of potentially thousands of synthesized alternatives, and a transform ...
Rhea, Randall W.
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Separation and Recovery of Geophysical Signals Based on the Kalman Filter with GRACE Gravity Data
Remote Sensing, 2019 Monthly gravitational field solutions as spherical harmonic coefficients produced by the GRACE satellite mission require post-processing to reduce the effects of shortwave-length noises and north⁻south stripe errors.
Xiaolong Wang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Breaking through political filter bubbles with transmedia campaigning
, 2021 Access to thesis restricted until 07/2024.Online filter bubbles created by algorithmic content personalization are intensifying partisan filter bubbles.
Hostetter, Austin B.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Preventing DDoS using Bloom Filter: A Survey
EAI Endorsed Transactions on Scalable Information Systems, 2018 Distributed Denial-of-Service (DDoS) is a menace for service provider and prominent issue in network security. Defeating or defending the DDoS is a prime challenge. DDoS make a service unavailable for a certain time.
Ripon Patgiri +2 more
doaj +1 more source