Results 61 to 70 of about 407,884 (290)
Information geometry of operator scaling
Linear Algebra and its Applications, 2022 Matrix scaling is a classical problem with a wide range of applications. It is known that the Sinkhorn algorithm for matrix scaling is interpreted as alternating e-projections from the viewpoint of classical information geometry. Recently, a generalization of matrix scaling to completely positive maps called operator scaling has been found to appear in
Takeru Matsuda, Tasuku Soma
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
AxiomsA critical processing step for AI algorithms is mapping the raw data to a landscape where the similarity of two data points is conveniently defined. Frequently, when the data points are compositions of probability functions, the similarity is reduced to ...
Giovanni Pistone, Muhammad Shoaib
doaj +1 more source
Challenges and Opportunities in Machine Learning for Geometry [PDF]
, 2023 Over the past few decades, the mathematical community has accumulated a significant amount of pure mathematical data, which has been analyzed through supervised, semi-supervised, and unsupervised machine learning techniques with remarkable results, e.g.,
Adrià Costa-Roig +5 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Global Solvably Closed Anabelian Geometry
, 2006 In this paper, we study the pro-Σ anabelian geometry of hyperbolic curves, where Σ is a nonempty set of prime numbers, over Galois groups of “solvably closed extensions” of number fields — i.e., infinite extensions of number fields which have ...
Mochizuki, Shinichi
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Nonparametric Information Geometry [PDF]
, 2013 Submitted for publication in the Proceedings od GSI2013 Aug 28-30 2013 ...
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source