Results 61 to 70 of about 16,524,402 (288)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Nonparametric Information Geometry [PDF]
, 2013 Submitted for publication in the Proceedings od GSI2013 Aug 28-30 2013 ...
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
AxiomsA critical processing step for AI algorithms is mapping the raw data to a landscape where the similarity of two data points is conveniently defined. Frequently, when the data points are compositions of probability functions, the similarity is reduced to ...
Giovanni Pistone, Muhammad Shoaib
doaj +1 more source
Normal forms in Poisson geometry [PDF]
, 2013 The structure of Poisson manifolds is highly nontrivial even locally. The first important result in this direction is Conn's linearization theorem around fixed points. One of the main results of this thesis (Theorem 2) is a normal form theorem in Poisson
Sub Algebra,Geometry&Mathem. Logic begr. +2 more
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Bookreview Geometry of algebraic curves. Volume II (Grundlehren der mathematischen Wissenschaften, 268) [PDF]
, 2012 Geometry of algebraic curves.
Sub Algebra,Geometry&Mathem. Logic begr. +2 more
core
Global Solvably Closed Anabelian Geometry [PDF]
, 2006 In this paper, we study the pro-Σ anabelian geometry of hyperbolic curves, where Σ is a nonempty set of prime numbers, over Galois groups of “solvably closed extensions” of number fields — i.e., infinite extensions of number fields which have ...
Mochizuki, Shinichi
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source