Results 71 to 80 of about 409,949 (290)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On the Fisher Metric of Conditional Probability Polytopes
Entropy, 2014 We consider three different approaches to define natural Riemannian metrics on polytopes of stochastic matrices. First, we define a natural class of stochastic maps between these polytopes and give a metric characterization of Chentsov type in terms of ...
Guido Montúfar, Johannes Rauh, Nihat Ay
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An introduction to differential geometry in econometrics [PDF]
, 2000 In this introductory chapter we seek to cover sufficient differential geometry in order to understand its application to Econometrics. It is not intended to be a comprehensive review of either differential geometric theory, nor of all the applications ...
Salmon, Mark H., Marriott, Paul
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Entropy, 2017 Information geometry enables a deeper understanding of the methods of statistical inference. In this paper, the problem of nonlinear parameter estimation is considered from a geometric viewpoint using a natural gradient descent on statistical manifolds ...
Yongqiang Cheng, Xuezhi Wang, Bill Moran
doaj +1 more source
Multisource Fusion UAV Cluster Cooperative Positioning Using Information Geometry
Remote Sensing, 2022 Due to the functional limitations of a single UAV, UAV clusters have become an important part of smart cities, and the relative positioning between UAVs is the core difficulty in UAV cluster applications.
Chengkai Tang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
The shaping of student knowledge: learning with dynamic geometry software [PDF]
, 2005 The focus of this paper is a software genre usually referred to as ‘dynamic geometry’ because of the ability of the user to dynamically manipulate geometrical figures created with the software tool. Using data from a longitudinal study of 12-13 students’
Jones, Keith
core