Results 71 to 80 of about 1,655,202 (268)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Entropy, 2017 Information geometry enables a deeper understanding of the methods of statistical inference. In this paper, the problem of nonlinear parameter estimation is considered from a geometric viewpoint using a natural gradient descent on statistical manifolds ...
Yongqiang Cheng, Xuezhi Wang, Bill Moran
doaj +1 more source
Multisource Fusion UAV Cluster Cooperative Positioning Using Information Geometry
Remote Sensing, 2022 Due to the functional limitations of a single UAV, UAV clusters have become an important part of smart cities, and the relative positioning between UAVs is the core difficulty in UAV cluster applications.
Chengkai Tang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Dynamics and the Emergence of Geometry in an Information Mesh
, 2020 The idea of a graph theoretical approach to modeling the emergence of a quantized geometry and consequently spacetime, has been proposed previously, but not well studied.
Tee, Philip
core +1 more source
Duality in Quantum Information Geometry [PDF]
Open Systems & Information Dynamics, 2004 Let [Formula: see text] be a separable Hilbert space. We consider the manifold [Formula: see text] consisting of density operators ρ on [Formula: see text] such that ρp is of trace class for some p ɛ (0, 1). We say [Formula: see text] is nearby ρ if there exists C > 1 such that C−1 ρ < σ < Cρ.
openaire +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Sentience and the Origins of Consciousness: From Cartesian Duality to Markovian Monism
Entropy, 2020 This essay addresses Cartesian duality and how its implicit dialectic might be repaired using physics and information theory. Our agenda is to describe a key distinction in the physical sciences that may provide a foundation for the distinction between ...
Karl J. Friston +2 more
doaj +1 more source
Information geometry of asymptotically AdS black holes
, 2009 We investigate thermodynamic geometries of two families of asymptotically Anti-de Sitter black holes, i.e. the Reissner-Nordstr\"om Anti-de Sitter in four dimensions and the BTZ black hole.
Jan E. Åman +5 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source