Results 81 to 90 of about 1,600,993 (289)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
The Information Geometry of UMAP
, 2023 12 pages, 2 figures, 3 tables ; Github repo (https://github.com/sashakolpakov/info-geometry-umap) ; to appear in Le ...
Kolpakov, Alexander, Rocke, Aidan
openaire +2 more sources
The Information Geometry of the One-Dimensional Potts Model [PDF]
, 2002 In various statistical-mechanical models the introduction of a metric onto the space of parameters (e.g. the temperature variable, $\beta$, and the external field variable, $h$, in the case of spin models) gives an alternative perspective on the phase ...
Abe R +16 more
core +4 more sources
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Information Geometry and Evolutionary Game Theory [PDF]
, 2009 The Shahshahani geometry of evolutionary game theory is realized as the information geometry of the simplex, deriving from the Fisher information metric of the manifold of categorical probability distributions.
Harper, Marc
core
Laplace's rule of succession in information geometry
, 2015 Laplace's "add-one" rule of succession modifies the observed frequencies in a sequence of heads and tails by adding one to the observed counts. This improves prediction by avoiding zero probabilities and corresponds to a uniform Bayesian prior on the ...
E Takimoto +6 more
core +2 more sources
Structural and functional characterization of chitinase from carnivorous plant Drosera adelae
FEBS Open Bio, EarlyView.A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda +7 more
wiley +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Information geometry of asymptotically AdS black holes
, 2009 We investigate thermodynamic geometries of two families of asymptotically Anti-de Sitter black holes, i.e. the Reissner-Nordstr\"om Anti-de Sitter in four dimensions and the BTZ black hole.
Jan E. Åman +5 more
core +1 more source
Central Dysmyelination in SSADH‐Deficient Humans and Mice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer +11 more
wiley +1 more source