Results 51 to 60 of about 2,349,275 (244)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Study and Application of Information Management System for In-Service Inspection of Nuclear Power Plant

Dianxin kexue, 2014
Based on summarizing of traditional in-service inspection（ISI）management mode，the ISI management system was studied and developed.Realization of NPP ISI informational management was achieved.Due to the application of the management system，problems ...
Xueliang Zhang, Yancheng Fan, Chunyang Wang, Guozheng Zhou   +3 more
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Sağlıklı Toplum İdeali Kapsamında Kişiselleştirilmiş Sağlık ve Beslenme Yaklaşımları: Proje Örnekleri Üzerinden Bir Analiz

Ankara Sağlık Bilimleri Dergisi
Günümüz dünyasında hızlı toplumsal ve teknolojik değişimlere bağlı olarak, bireysel sağlık yönetimi giderek daha fazla önem kazanmaktadır. Bu çerçevede kişiye özel sağlık ve beslenme uygulamaları, bireylerin özgün ihtiyaçlarına yönelik yenilikçi çözümler
Semanur Çelik, Erdal Eke
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Construction of a chain information management system for pressure injuries based on evidence-based medicine and the Delphi method (基于循证医学与德尔菲法的压力性损伤链式信息化管理系统构建研究)

中西医结合护理
Objective In order to address the issues of delayed assessment and fragmented interventions in routine management of pressure injury (PI), this study aims to constructs chain-based information management system grounded in evidence-based practices and ...
HE Xuxu (何绪绪), ZHAO Jieqiong (赵洁琼)   +1 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Reporting on the Development of a Web-Based Prototype Dashboard for Construction Design Managers, Achieved through Design Science Research Methodology (DSRM)

Buildings
Construction Design Management (DM) involves the coordination of design processes and activities to ensure quality project design, yet it involves many challenges.
Barry Gledson, Kay Rogage, Anna Thompson, Hazel Ponton   +3 more
doaj   +1 more source