Results 61 to 70 of about 3,535,553 (315)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

A guide to the project management body of knowledge: PMBOK guide

open access: yes, 2013
A Guide to the Project Management Body of Knowledge (PMBOK Guide) Fifth Edition reflects the collaboration and knowledge of working project managers and provides the fundamentals of project management as they apply to a wide range of projects.
Project Management Institute
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

An adaptive environment for personal information management

open access: yes, 1999
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This dissertation reports the results of research into the provision of adaptive user interfaces to support individuals in the management of their personal ...
Keeble, Richard
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Study and Application of Information Management System for In-Service Inspection of Nuclear Power Plant

open access: yesDianxin kexue, 2014
Based on summarizing of traditional in-service inspection(ISI)management mode,the ISI management system was studied and developed.Realization of NPP ISI informational management was achieved.Due to the application of the management system,problems ...
Xueliang Zhang   +3 more
doaj  

Determinants of knowledge management with information technology support impact on firm performance. Information Technology and Management

open access: yes, 2013
[[abstract]]The relationship between knowledge management (KM) and firm performance has been the subject of discussion in management literature. However, certain studies have found a significant link between KM and firm performance, whereas others have ...
莊淑惠;Shu-Hui Chuang;Chechen Liao;Shinyi Lin
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Sağlıklı Toplum İdeali Kapsamında Kişiselleştirilmiş Sağlık ve Beslenme Yaklaşımları: Proje Örnekleri Üzerinden Bir Analiz

open access: yesAnkara Sağlık Bilimleri Dergisi
Günümüz dünyasında hızlı toplumsal ve teknolojik değişimlere bağlı olarak, bireysel sağlık yönetimi giderek daha fazla önem kazanmaktadır. Bu çerçevede kişiye özel sağlık ve beslenme uygulamaları, bireylerin özgün ihtiyaçlarına yönelik yenilikçi çözümler
Semanur Çelik, Erdal Eke
doaj   +1 more source

Knowledge-based Management Information Systems for the effective business performance of SMEs

open access: yes, 2009
This study attempts to advance current thinking around Knowledge Management Systems (KMS) and Management Information Systems (MIS) by proposing integration into a holistic information system - Knowledge-based Management Information System (KBMIS).
Green, Gill, Liu, Lu, Qi, Baomin
core  

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