Results 51 to 60 of about 3,535,553 (315)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Information management technologies in customer service management

Вестник Северо-Кавказского федерального университета
Introduction. Information flows in the digital economy are becoming a new type of assets of the organization. Information management solves two important tasks in the management of an organization: on the one hand, it coordinates information flow ...
A. N. Aleksakhin, S. A. Aleksakhina, M. A. Shoshin, V. A. Shumeiko   +3 more
doaj   +1 more source

An Overview of Information Management and Information Managers

Proceedings of the Annual Conference of CAIS / Actes du congrès annuel de l'ACSI, 2013
From the 1994 CAIS Conference:The Information Industry in TransitionMcGill University, Montreal, Quebec. May 25 - 27, 1994.This paper introduces and defines the subject of Information Management and describes what Information Mangers do, pointing out connections with related fields and professions. Key challenges for information managers are emphasized.
openaire   +1 more source

Data Security in Healthcare Systems: Integration of Information Security and Information Management

, 2023
Abdelaziz, A., & Mahmoud, A. N. (2023). Data Security in Healthcare Systems: Integration of Information Security and Information Management. Journal of Cybersecurity and Information Management, 11(2), 17-26.
Mahmoud, Alia Nabil, Ahmed Abdelaziz, Abdelaziz, Ahmed, Alia N. Mahmoud   +3 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Editorial: Business and Information Management Realities in a World of Global Disruption and 4IR

African Journal of Inter-Multidisciplinary Studies
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Trisha Ramsuraj, Peggy Mthalane
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

La discipline archivistique au Canada : état de développement et perspectives d’avenir

In Situ, 2016
Today, in Canada as elsewhere, ‘archival work’ has become a profession and a recognised discipline in universities, research services and society in general.
Carol Couture
doaj   +1 more source