Results 141 to 150 of about 2,191,422 (217)

Effect of Continuous Nursing Based on IKAP Theory on Periodontal Indicators and Self-Management Ability of Patients With Periodontal Disease. [PDF]

Int Dent J
Yao X, Cheng Z.
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Supporting nurses to improve clinical trial discussions with patients with lung cancer using the Lung I-ACT tool: a mixed methods pilot study. [PDF]

BMJ Open Respir Res
Lond B, Dodd C, Davey Z, Williamson IR, Rawlinson J, McPhelim J, Darlison L, Henshall C.   +7 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Breast cancer screening in Europe and the role of general practitioners: A 32-country comparative survey. [PDF]

Eur J Gen Pract
Papageorgiou DI, Smyrnakis E, Harris M, Skuja I, Adžić ZO, Apostolova G, Bensemmane S, Brekke M, Buczkowski K, Buono N, Burgers J, Danilenko J, Högberg C, Kafadar D, Koskela T, Kral N, Kraxner R, Küppers L, Legoff D, Marzo-Castillejo M, Pless A, Ponzel N, Puia A, Radzevičienė-Jurgutė R, Redmond P, Särgava K, Šter MP, Sulashvili M, Vedsted P, Wöstmann X, Zafirovska M, Zaidan R, Hoffman R.   +32 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The Role of the Pediatric Pharmacist in Precision Medicine and Clinical Pharmacogenomics for Children. [PDF]

J Pediatr Pharmacol Ther
Cook KJ, Duong BQ, Kim H, Lamb N, Nguyen JQ.   +4 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source