Results 51 to 60 of about 1,048,956 (299)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

SET-THEORETIC MODELS AND UNIFIED METHODS OF INFORMATION RESOURCES PROCESSING IN E-BUSINESS SYSTEMS [PDF]

Applied Computer Science, 2014
In the given article is functional logistic model of commercial content processing as the content life cycle stage in electronic commerce systems proposed.
Victoria VYSOTSKA, Lyubomyr CHYRUN
doaj  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

FEATURES OF INFORMATION RESOURCES PROCESSING IN ELECTRONIC CONTENT COMMERCE [PDF]

Applied Computer Science, 2014
Some solutions of main problems of content e-commerce and content management services are described in the paper. Content lifecycle model in electronic commerce systems is considered.
Andriy BERKO, Victoria VYSOTSKA, Lyubomyr CHYRUN   +2 more
doaj  

Complexity of reference consultations for undergraduate and graduate students in an academic library [PDF]

Knowledge & Performance Management
Effective resource allocation is critical for academic libraries that offer reference consultations and information literacy instruction to support student success.
Naděžda Firsová, Jana Hinke, Luboš Smutka   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Library Anxiety of Residents in Use of Information Sources and Electronic Services Based on Localized Bostick Scale

پیاورد سلامت, 2020
Background and aim: A Library is a safe place to research and study for some students, but it creates anxiety for others. The main purpose of this research is to investigate the library anxiety among Kermanshah University of Medical Sciences(KUMS ...
Farideh Akbarzadeh, Zahed Bigdeli
doaj  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Designing a Mini-Program for Culture Learning and Creative Product Customization: DIY RADP

Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019
Taking Chinese royal architecture decorative patterns as an example, this paper explores an overall socioeconomic framework of culture learning and culture creative product customization as well as the technological framework for developing a WeChat mini-
Xiaoshuang Jia, Yuan Liang, Kexin Wang, Shengnan Yao, Leiqian Han, Xingzhuan Chai   +5 more
doaj   +1 more source