Results 91 to 100 of about 10,035,302 (334)

Software Support for Discourse-Based Textual Information Analysis: A Systematic Literature Review and Software Guidelines in Practice

Information, 2020
The intrinsic characteristics of humanities research require technological support and software assistance that also necessarily goes through the analysis of textual narratives. When these narratives become increasingly complex, pragmatics analysis (i.e.,
Patricia Martin-Rodilla, Miguel Sánchez
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Optimizing poultry audio signal classification with deep learning and burn layer fusion

Journal of Big Data
This study introduces a novel deep learning-based approach for classifying poultry audio signals, incorporating a custom Burn Layer to enhance model robustness.
Esraa Hassan, Samar Elbedwehy, Mahmoud Y. Shams, Tarek Abd El-Hafeez, Nora El-Rashidy   +4 more
doaj   +1 more source

Robust Information Retrieval

Proceedings of the 47th International ACM SIGIR Conference on Research and Development in Information Retrieval
Beyond effectiveness, the robustness of an information retrieval (IR) system is increasingly attracting attention. When deployed, a critical technology such as IR should not only deliver strong performance on average but also have the ability to handle a variety of exceptional situations.
Yu-An Liu, Ruqing Zhang, Jiafeng Guo, Maarten de Rijke   +3 more
openaire   +2 more sources

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Privacy-Preserving Data Sharing and Computing for Outsourced Policy Iteration with Attempt Records from Multiple Users

Applied Sciences
Reinforcement learning is a machine learning framework that relies on a lot of trial-and-error processes to learn the best policy to maximize the cumulative reward through the interaction between the agent and the environment.
Bangyan Chen, Jun Ye
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Routing Protocol for Underwater Wireless Sensor Networks Based on a Trust Model and Void-Avoided Algorithm

Sensors
Underwater wireless sensor networks have a wide range of application prospects in important fields such as ocean exploration and underwater environment monitoring. However, the influence of complex underwater environments makes underwater wireless sensor
Jun Ye, Weili Jiang
doaj   +1 more source