Results 71 to 80 of about 617,850 (247)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Optimizing IoT intrusion detection with cosine similarity based dataset balancing and hybrid deep learning

Scientific Reports
With IoT networks expected to exceed 29 billion connected devices by 2030, the risk of cyberattacks has never been higher. As more devices come online, the attack surface for hackers continues to expand, making cybersecurity a pressing concern. Intrusion
Arvind Prasad, Wael Mohammad Alenazy, Naved Ahmad, Gauhar Ali, Hanaa A. Abdallah, Sadique Ahmad   +5 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Comparative evaluation of data imbalance addressing techniques for CNN-based insider threat detection

Scientific Reports
Insider threats pose a significant challenge in cybersecurity, demanding advanced detection methods for effective risk mitigation. This paper presents a comparative evaluation of data imbalance addressing techniques for CNN-based insider threat detection.
Taher Al-Shehari, Mohammed Kadrie, Mohammed Nasser Al-Mhiqani, Taha Alfakih, Hussain Alsalman, Mueen Uddin, Syed Sajid Ullah, Abdulhalim Dandoush   +7 more
doaj   +1 more source

A New Encryption Algorithm Utilizing DNA Subsequence Operations for Color Images

AppliedMath
The computer network has fundamentally transformed modern interactions, enabling the effortless transmission of multimedia data. However, the openness of these networks necessitates heightened attention to the security and confidentiality of multimedia ...
Saeed Mirzajani, Seyed Shahabeddin Moafimadani, Majid Roohi   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Blockchain with secure data transactions and energy trading model over the internet of electric vehicles

Scientific Reports
The rise of Electric Vehicles (EVs) has introduced significant advancement and evolution in the electricity market. In smart transportation, the EVs have earned more popularity because of its numerous benefits including lower carbon footprints, higher ...
Taher Al-Shehari, Mohammed Kadrie, Taha Alfakih, Hussain Alsalman, T. Kuntavai, R. G. Vidhya, C. Dhanamjayulu, Shubhi Shukla, Baseem Khan   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source