Results 101 to 110 of about 7,205,337 (291)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

STCD: efficient Siamese transformers-based change detection method for remote sensing images

Geo-spatial Information Science
Remote sensing Change Detection (CD) involves identifying changing regions of interest in bi-temporal remote sensing images. CD technology has rapidly developed in recent years through the powerful learning ability of Convolutional Neural Networks (CNN),
Decheng Wang, Xiangning Chen, Ningbo Guo, Hui Yi, Yinan Li   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Design of an Integrated Space-Based Information Support Digital Infrastructure

IEEE Access
To address systemic challenges including decentralized construction, functional redundancy, and network heterogeneity in space-based information systems in the New Space Age, For the first time, this study formulates a unified, modular, and service ...
Pengbo Li, Gang Wan, Zhongmin Pei
doaj   +1 more source

Combining speed information across space

Vision Research, 1995
We used speed discrimination tasks to measure the ability of observers to combine speed information from multiple stimuli distributed across space. We compared speed discrimination thresholds in a classical discrimination paradigm to those in an uncertainty/search paradigm. Thresholds were measured using a temporal two-interval forced-choice design. In
Verghese, Preeti, Stone, Leland S.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ВЗАИМОСВЯЗЬ ИНФОРМАЦИОННОГО ПРОСТРАНСТВА И ВЫБОРА МОДЕЛИ ОТКЛОНЯЮЩЕГОСЯ ПОВЕДЕНИЯ ШКОЛЬНИКАМИ

Sovremennye Issledovaniâ Socialʹnyh Problem, 2015
В статье представлено понимание проблемы экспансивно развивающегося информационного пространства как фактора влияющего на социализацию школьников. Дается характеристика современного информационного пространства, анализируются подходы к его изучению ...
Denis Alexandrovich Davydov, Aleksandr Sergeevich Yermolayev, Oksana Vladimirovna Kopovaya   +2 more
doaj   +1 more source

Information Operators in Categorical Information Spaces [PDF]

Information, 2010
The general theory of information (GTI) is a synthetic approach, which reveals the essence of information, organizing and encompassing all main directions in information theory. On the methodological level, it is formulated as system of principles explaining what information is and how to measure information.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

SDGANets: a semantically enhanced dual graph-aware network for affine and registration of remote sensing images

Complex & Intelligent Systems
Remote sensing image pairs of different time phases have complex and changeable semantic contents, and traditional convolutional registration methods are challenging in modeling subtle local changes and global large-scale deformation differences in ...
Xie Zhuli, Wan Gang, Liu Jia, Bu Dongdong   +3 more
doaj   +1 more source